Innovations in Regenerative Medicine That Improve the Results of Stem Cell Treatment: 3D Cultivation, In Vivo Modeling of Stem Cell Niche, and Prenatal Stem Cells Exosomes

    January 2019 in “ Cell & developmental biology ”
    Abhijit Bopardikar
    TLDR 3D cultivation and prenatal stem cell exosomes improve stem cell treatment results, especially for hair loss and age-related issues.
    The study addressed the challenge of hair loss, particularly in large areas of alopecia where patients lack sufficient hair for auto-transplantation. Traditional 2D cultures for multiplying hair follicle stem cells (SCs) were unsuccessful, leading to the development of a 3D culture technology that successfully formed new hair follicles suitable for transplantation. The research also explored the use of Fetal Tissue Extracts (FTEs) to create a supportive microenvironment for SCs, showing high efficacy in treating liver cirrhosis and non-healing wounds in patients unresponsive to previous SC treatments. The combination of SC transplantation and SC-derived exosomes in a rejuvenation program yielded optimal therapeutic results in 78.9% of patients, significantly reducing biological age and frailty index, thus lowering the risk of age-related diseases. The findings highlighted the potential of 3D cultivation, in vivo modeling of SC niches, and prenatal SC exosomes to enhance the outcomes of SC-based regenerative medicine.
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