7 citations
,
October 2000 in “Allergo Journal” Stress may affect hair growth by influencing hair follicle development and could contribute to hair loss.
21 citations
,
November 2022 in “Frontiers in immunology” This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.
1 citations
,
July 2021 in “Hair transplant forum international” This study found a 93.5% increase in nonvellus hair after 6 months of daily topical CBD application on the scalp in individuals with androgenetic alopecia, with no reported adverse effects.
142 citations
,
March 2019 in “Molecules/Molecules online/Molecules annual” This review discusses the role of the endocannabinoid system in skin health and disease, highlighting its potential for future research and applications, but reports no new experimental results.
124 citations
,
January 2012 in “Journal of Allergy and Clinical Immunology” This study found that activation of cannabinoid 1 receptors in human scalp hair follicles may limit excessive mast cell activation and maturation, suggesting a potential therapeutic strategy for managing MC-dependent skin diseases.
3 citations
,
December 2022 in “Cells” This review examines the role of cannabinoid compounds in treating various skin conditions and suggests their potential as systemic and topical therapies, but it reports no new experimental results.
28 citations
,
January 2017 in “EBioMedicine” This study discusses potential anti-inflammatory roles of endocannabinoid system modulation and phytocannabinoids in skin health, but reports no new clinical results; the authors emphasize the need for further clinical exploration.
December 2024 in “Frontiers in Genetics” This review discusses the genetic causes and pathogenesis of Olmsted syndrome, emphasizing the potential for a genotype-phenotype correlation due to TRPV3 mutations, and explores avenues for individualized treatment developments for this condition.
23 citations
,
October 2009 in “Gastroenterology” This article reviews the multifaceted roles of vitamin D beyond bone health and notes its potential involvement in reducing risks of certain cancers and autoimmune diseases, but it presents no new clinical results.
1 citations
,
January 2024 in “International journal of molecular sciences” This review article addresses how the TRPV4 ion channel helps cells respond to mechanical and environmental stimuli, discussing its role in calcium signaling crucial for tissue repair and fibrosis across various organ systems, and highlighting potential therapeutic targets from animal and disease models.
2 citations
,
January 2022 in “BioMed Research International” The researchers concluded that baicalin may promote hair growth and follicle proliferation by activating the AKT pathway, suggesting its potential as a treatment for alopecia.
71 citations
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May 2007 in “The FASEB journal” This study found that human hair follicles express erythropoietin and its receptor, suggesting these follicles may use erythropoietin signaling to modulate apoptosis under stress conditions like hypoxia and chemotherapy.
24 citations
,
December 2009 in “Future Medicinal Chemistry” This study identified new potential targets and indications for several marketed drugs using in silico profiling, suggesting opportunities for drug repositioning.
January 2022 in “Clinical dermatology open access journal” This review summarizes research on cannabinoids like CBD and THCV, reporting that they improve hair growth in patients with androgenetic alopecia when applied topically, with CBD showing a dose-dependent effect.
9 citations
,
January 2005 in “Experimental dermatology” The researchers observed that normal murine hair follicles are direct targets for melatonin, with receptor expression varying throughout the hair cycle, suggesting melatonin's role in hair cycle control.
68 citations
,
July 2011 in “Journal of Biochemistry/The journal of biochemistry” This review discusses newly identified non-Edg family lysophosphatidic acid receptors, detailing their roles in vascular development, platelet activation, and hair growth, and reports no clinical results.
3 citations
,
November 2019 in “Journal of Investigative Dermatology” In this study, researchers reported that adenosine stimulated hair shaft elongation in cultured human hair follicles by promoting proliferation and prolonging the anagen phase, suggesting the A2B adenosine receptor in outer root sheath keratinocytes as a promising target for treating hair growth disorders like alopecia.
2 citations
,
January 2025 in “Pharmaceutical Research” This article reviews the possible therapeutic activities of Angelica gigas Nakai root extracts and their components, noting their potential effects on neuro-cognitive, metabolic, and other health conditions, and reports no new clinical results.
1 citations
,
November 2023 in “International journal of molecular sciences” This article highlights that while cannabinoids show potential for treating various skin conditions, current evidence is largely preclinical, with a need for comprehensive clinical trials to confirm these promising effects.
May 2020 in “Authorea (Authorea)” This review discusses the diverse functions and therapeutic potential of ectopic olfactory receptors throughout the body, emphasizing their roles in various cellular processes and potential in cancer detection and therapy, but reports no new clinical results.
32 citations
,
January 2017 in “PLoS ONE” This study found that adiponectin significantly enhanced lipid production in human sebaceous glands and may be a potential target for treating conditions with reduced sebum production.
January 2024 in “Clinical dermatology open access journal” This paper reviews existing research on the cosmetic benefits of hemp-derived cannabinoids for skin and hair, highlighting their unique mechanisms of action, while discussing formulation, legal, and regulatory challenges associated with using these compounds in cosmetic products.
124 citations
,
December 2016 in “Pharmaceuticals” This review discusses the functions and potential therapeutic targeting of TRP ion channels in the skin, noting their involvement in both physiological processes and various pathological conditions, but reports no new experimental results.
58 citations
,
March 2011 in “Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere/Pflügers Archiv” Hormones and signaling pathways control sebaceous gland function and could help treat acne.
61 citations
,
October 2011 in “Experimental dermatology” This review discusses the neurobiology and proposed mechanisms of scalp itch, but it does not report new clinical findings, highlighting the need for further research in this area.
1 citations
,
February 2025 in “South Asian Research Journal of Pharmaceutical Sciences” This study used in-silico molecular docking to evaluate the antidiabetic potential of Eclipta alba leaf flavonoids, finding that compounds like apigenin, syringic acid, and vanillic acid effectively bind to the target protein aldose reductase, suggesting a promising inhibitory action.
108 citations
,
July 2004 in “American Journal of Pathology” This study suggests that nerve growth factor plays a crucial role in the stress-induced termination of hair growth in mice, and its antagonism might offer a therapeutic approach to mitigate stress-related hair loss.
77 citations
,
September 2017 in “Journal of Investigative Dermatology” This study found that TRPV3 ion channels on human epidermal keratinocytes suppress cell proliferation, induce cell death, and trigger a proinflammatory response, suggesting a role in cutaneous inflammatory processes.
224 citations
,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.
20 citations
,
January 2015 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” This review discusses lysophosphatidic acid's role in neuropathic pain and cholestatic itch, highlighting its complex signaling pathways, but reports no new clinical results.