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This study found that the dysfunction of hair follicle dermal stem cells with age contributes to hair follicle aging and hair loss in mice.

This study found that among women with polycystic ovary syndrome, insulin resistance was more strongly associated with cardio-metabolic abnormalities than β-cell dysfunction, and they showed different correlations with obesity.

This study found that H-Ras activation in aged mouse skin leads to increased dysplasia and progression to in situ squamous cell carcinoma, highlighting an age-linked connection between immune changes, senescence, and cancer risk.

This study found that telomere shortening disrupts BMP/pSmad/P63 signaling, leading to skin atrophy via Follistatin up-regulation, and suggests potential therapeutic targets.

This review discusses the impaired functionality of regulatory T cells in the pancreas during the development of Type 1 diabetes, highlighting their role in disease pathogenesis, potential of Treg-based therapies, and challenges in clinical applications.

This study explored the complex roles of niche cells in regulating hair follicle stem cells, identifying specific cell functions such as signaling, sensing, and relaying messages, which could provide insights into treating hair loss conditions like androgenetic alopecia and alopecia areata.

This study identified a subpopulation of neural crest-derived progenitor cells in human corneal endothelial tissue from normal and Fuchs endothelial corneal dystrophy donors, which may have potential for future cell therapy development.

Hormones cause hair loss by affecting cell growth and weakening cell attraction.

This review analyzes the interplay between atopic dermatitis and alopecia areata, suggesting that epidermal barrier dysfunction and genetic predispositions exacerbate both conditions through immune responses.

This review highlights how diabetes affects stem and progenitor cells through altered signaling and homeostasis, impacting tissue function and complicating diabetic therapy efforts; new clinical results are not presented.

This review discusses the role of the TCL1 transgenic mouse model in understanding chronic lymphocytic leukemia biology and highlights the importance of exploring new pathogenetic and therapeutic targets.

This study found that human γδTregs promoted hair regrowth and restored hair follicle immune privilege in a model of alopecia areata, suggesting potential for cell-based therapy in autoimmune diseases.

This review highlights the role of disrupted glycolysis in exacerbating reproductive and metabolic abnormalities in PCOS and suggests that agents like metformin and resveratrol may help restore glycolytic balance and improve ovarian function.

This study found that upcycled postbiotic cell-free supernatants from Limosilactobacillus fermentum MG901 and MG4237 protected human dermal papilla cells from oxidative stress, enhancing wound-healing capacity and mitochondrial function, suggesting potential as a sustainable cosmetic ingredient for hair loss alleviation.

This study found that testosterone enhances insulin secretion in human pancreatic islets by being converted into DHT and E2, processes that are necessary for this effect.

This review discusses the potential autoimmune pathogenesis and various contributing factors of alopecia areata, noting that current treatments remain palliative while emerging therapies offer new hope for extensive cases.

This review discusses the mechanisms of skin barrier impairment in acne vulgaris and suggests strategies for its repair but reports no new clinical results.

This article reviews potential factors influencing Behçet's disease, like increased neutrophil functions, immunological changes, stress, and hormonal alterations, but it presents no new clinical results.

This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.

This study observed that Ptprq mutant mice exhibit significant abnormalities in hair bundle structure and vestibular dysfunction, suggesting similar issues may contribute to hearing loss and vestibular problems in humans with PTPRQ mutations.

This study identified new genes and compounds affecting hair cell survival during ototoxin exposure using the zebrafish model, potentially aiding in understanding and preventing hearing loss and balance disorders in humans.

This study demonstrates a method using intravital imaging to observe sensory hair-cell development and regeneration in zebrafish, which may facilitate assays for drug discovery related to aural function preservation.

This study found that minoxidil stimulates the Kir6.2/SUR2 potassium channel, leading to tumor growth arrest in an ovarian cancer xenograft model by disrupting mitochondrial function and inducing cell death.

This study discusses how redox imbalance, specifically through reduced Insulin-like Growth Factor-1 mediated by the transcription factor JunB and sphingolipid metabolism changes, contributes to skin aging by depleting stem cell pools and altering the extracellular matrix, ultimately impacting skin integrity and function.

This study found that diazepam had an exaggerated effect on GABA-related inhibitory tone in diabetic neuropathic mice compared to normal mice, potentially due to mitochondrial dysfunction affecting neurosteroid synthesis.

This review highlights that the RNA modification N⁶-methyladenosine (m⁶A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.

This study synthesizes knowledge of how dendritic cell signals, epithelial integrins, and fibroblast activity converge on TGF-β1 to maintain or disrupt skin healing, contrasting normal and fibrotic scar formation and suggesting possible integrin and immune-targeted treatments for skin fibrosis.

This study provides a comprehensive overview of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (HUCMSC-EVs), suggesting their potential to combat aging and alleviate age-related disorders by rejuvenating multiple organs in animal models and discussing engineering strategies to harness their full anti-aging potential.

This article reviews potential pathomechanisms of vitiligo, emphasizing membrane alterations involving cholesterol and cardiolipin, but reports no new clinical findings.

This study suggests that black ginseng concentrate protects human follicle dermal papilla cells against oxidative stress, potentially offering a natural approach to prevent cellular dysfunction linked to hair loss.