Intracrine Testosterone Activation in Human Pancreatic Beta-Cells Stimulates Insulin Secretion

    August 2020 in “ Diabetes ”
    Weiwei Xu, Lina Schiffer, M.M. Fahd Qadir, Yan-Qing Zhang, James P. Hawley, Paula Mota de Sa, Brian G. Keevil, Hongju Wu, Wiebke Arlt, Franck Mauvais-Jarvis
    Image of study
    TLDR Testosterone helps human pancreatic cells increase insulin release.
    The study found that human pancreatic β-cells express enzymes that convert testosterone (T) to dihydrotestosterone (DHT) and estradiol (E2), which are necessary for the enhancement of glucose-stimulated insulin secretion (GSIS). The conversion of T to DHT and E2 was shown to be inhibited by 5α-reductase and aromatase inhibitors, respectively. The research suggests that these inhibitors could affect GSIS and potentially predispose older men to type 2 diabetes, while in women with androgen excess, intracrine androgen activation may contribute to β-cell dysfunction. The study concludes that β-cells in human pancreatic islets can locally activate sex steroids from circulating testosterone, which is crucial for their role in insulin secretion.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Is this broscience? From More Plates, More Dates

      in Research/Science  22 upvotes 8 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community 5 months of nuking T, 2 months of minoxidil

      in Transgender  485 upvotes 2 months ago
      The user transitioned from finasteride to Cyproterone and started using Minoxidil, resulting in healthier hair and regrowth. They plan to wean off Minoxidil in a year, depending on regrowth.

      community Topical finasteride has affected my hormones

      in Finasteride/Dutasteride  26 upvotes 10 months ago
      A 21-year-old experienced hormone changes after using self-made topical finasteride for hair loss, including a 20% decrease in DHT, a 47% increase in testosterone, and a 39% increase in estradiol. The user previously used minoxidil and microneedling but is now seeking ways to balance hormones, possibly through supplements or dosage adjustments.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 1 year ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

      community after several weeks of research, here's the stack I've decided on

      in Finasteride/Dutasteride  43 upvotes 3 months ago
      A 23-year-old experiencing diffuse hair thinning has chosen a treatment stack including topical finasteride, a blend of rosemary, peppermint, and pumpkin seed oils, procyanidine B2 spray, ketoconazole shampoo, and scalp massages. They avoid minoxidil due to family history of side effects and oral finasteride due to high estrogen levels.

    Similar Research

    5 / 1000+ results