Endocrine Profile of the VCD-Induced Perimenopausal Model Rat
December 2019
in “
PloS one
”
New to Estradiol? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, the authors concluded that the VCD-induced follicular depletion rat model can effectively simulate the perimenopause transition, with hormonal changes distinguishing early/mid-transition from late transition to estropause.
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The study investigated the endocrine changes in a VCD-induced perimenopausal rat model, involving 25 rats. VCD treatment led to significant hormonal alterations, including lower AMH and progesterone levels, and normal estradiol, LH, and FSH levels from 70 to 90 days post-treatment. By 100 days, VCD-treated rats exhibited increased FSH and DHT levels, irregular/elongated estrous cycles, and a significant reduction in AMH, indicating the onset of estropause. These findings suggested that VCD treatment accelerated the transition to ovarian failure, mimicking hormonal changes observed in late perimenopausal women, and highlighted the potential of this model for studying perimenopausal endocrine dynamics.
