Cutis Verticis Gyrata Heralding a Diagnosis of Primary Systemic Amyloidosis in a Patient with Cardioembolic Stroke

A 48-year-old woman presented with a cardioembolic stroke and was found to have cutis verticis gyrata (CVG), a rare scalp condition. Her CVG, along with other symptoms like macroglossia and proteinuria, led to the diagnosis of primary systemic amyloidosis. Despite initial stroke treatment, further tests confirmed amyloidosis through scalp and tongue biopsies. The patient was treated with a combination of apixaban and a chemotherapy regimen (bortezomib, cyclophosphamide, and dexamethasone), showing improvement at a 3-month follow-up. This case highlights the importance of recognizing CVG as a potential early indicator of systemic amyloidosis.