Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches

Acne vulgaris is linked to skin barrier dysfunction, influenced by factors such as excessive sebum production, inflammation, and environmental stressors. Traditional treatments often neglect skin barrier repair, resulting in suboptimal outcomes. Recent studies emphasize the importance of addressing skin barrier issues, as compromised barriers are evidenced by increased transepidermal water loss and altered microbial diversity. Repair strategies, including cosmeceuticals, low-level laser therapy, and mesotherapy, aim to restore barrier function by modulating lipids and reducing inflammation. Mesotherapy shows promise but requires further research to confirm its efficacy and safety. Understanding and repairing the skin barrier is crucial for effective acne management and preventing recurrence.