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In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus Racemosus Root as Anti-Sebum and Pore-Minimizing Active Ingredients

research In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients

8 citations , February 2022 in “Molecules”

This study found that Asparagus racemosus root extract significantly reduced facial sebum production and pore size in male volunteers, suggesting potential application as an anti-sebum ingredient in cosmetics.

research Intradermal Botulinum Toxin A Injection for Scalp Sebum Secretion Regulation: A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Prospective Study in Chinese Subjects

4 citations , August 2022 in “Aesthetic Surgery Journal”

This study found that one session of intradermal botulinum toxin type A injection decreased scalp sebum secretion and perception of greasiness more effectively than saline for up to 3 months.

research Evaluation of the serum level of regulation upon activation of normal T-cell expressed and secreted protein in different types of alopecia areata

May 2015 in “Journal of the Egyptian Women's Dermatologic Society /Journal of the Egyptian Women's Dermatologic Society”

research Minoxidil and male-pattern alopecia: a potential role for a local regulator of sebum secretion with vasoconstrictive effects?

5 citations , November 1999 in “Medical Hypotheses”

Minoxidil, a common hair loss treatment, might work by counteracting a hormone that reduces hair growth and promotes hair loss.

research Supramolecular Adenosine-Based Skin Delivery System for Hair Regulation and Restoration

January 2026 in “Journal of Materials Chemistry B”

In this study, researchers addressed the limitations of adenosine's practical application in treating inflammation, oxidative stress, and tissue repair due to its poor water solubility and low transdermal permeability. Results are not reported in the abstract.

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Community Join

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community Sebum production even on dutasteride, and its relation to MPB.

in Finasteride/Dutasteride 6 upvotes 9 months ago

The conversation discusses managing hair loss and scalp issues, with users sharing experiences using treatments like dutasteride, finasteride, ketoconazole, sulfur soap, and topical anti-androgens. Suggestions include trying sulfur soap, scalp massages, spironolactone, and dietary changes to reduce sebum production and dandruff.

community Can the ingredients in a sebum-regulating shampoo induce hair diameter reduction?

2 upvotes 1 year ago

A user experienced hair thinning and scalp issues after using a sebum-regulating shampoo and perm treatments. They are advised to consider potential allergies, try a simple shampoo, and research treatments like finasteride for possible male pattern baldness.

community 800pg/mL serum DHT after almost 2 years on dht blockers

in Finasteride/Dutasteride 3 upvotes 1 year ago

The user has been using dutasteride and finasteride but still experiences hair loss and high DHT levels. They plan to try topical finasteride and RU58841 while continuing dutasteride to see if topicals are more effective.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

121 upvotes 2 years ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

7 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

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Learn

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learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Stem Cell Factor

learn sh-Polypeptide-7

learn Baicapil

Could a daily serum with Baicapil help revive dormant hair follicles before it’s too late? Yes, a daily serum with Baicapil may help revive dormant hair follicles.

learn Bimatoprost

Can a lash-growth serum like bimatoprost actually work for your scalp? Bimatoprost (Latisse) is approved for eyelashes, not the scalp; two Allergan phase 2 trials in men with androgenetic alopecia posted results to ClinicalTrials.gov but were never published in a peer-reviewed journal, so scalp use remains off-label and experimental.

learn Hyaluronic Acid

What’s the difference between using hyaluronic acid as a serum on the scalp versus taking it as a supplement? Hyaluronic acid serum hydrates the scalp surface, while supplements may support overall hair health.

learn Exosomes

Are exosomes applied as a serum, an injection, or combined with other hair treatments? Exosomes are typically injected directly or combined with other hair treatments.

learn Rapamycin

Are there any visible side effects when using rapamycin cream or serum on the scalp? Visible side effects may include skin irritation or redness when using rapamycin on the scalp.

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