221 citations
,
July 2012 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that the circadian clock in mouse skin regulates cell proliferation and affects sensitivity to UVB-induced DNA damage, with potential implications for understanding human skin cancer risk.
184 citations
,
October 2007 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that sulforaphane-rich broccoli sprout extracts reduced UV-induced erythema by 37.7% in humans, suggesting a protective strategy against UVR damage.
148 citations
,
May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that mice lacking the vitamin D receptor (VDR) developed skin tumors more rapidly than those with normal VDR activity, regardless of 1,25-dihydroxyvitamin D(3) presence.
109 citations
,
September 1999 in “Archives of Dermatology” This study found that the combination of fluticasone propionate and UV-A was much more effective for vitiligo repigmentation than either treatment used alone, with no significant adverse effects reported.
101 citations
,
July 1998 in “Journal of Investigative Dermatology” This study found that UV exposure in human skin induces IL-10 production by macrophages, while Langerhans cells are depleted and their IL-12 production is downregulated.
99 citations
,
April 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that human hair follicles serve as a crucial reservoir for Langerhans cells, which repopulate the epidermis depleted by ultraviolet B exposure.
76 citations
,
February 2007 in “Cancer Research” This study reported that UVR induced PKCε phosphorylation of Stat3 in transgenic mice, suggesting a role in enhancing sensitivity to UVR-related skin cancer development.
52 citations
,
January 2016 in “Brazilian Journal of Medical and Biological Research” In this study, patients with generalized vitiligo treated with a combination of oral compound glycyrrhizin and UVB light showed the most effective repigmentation and disease stabilization compared to other treatment groups.
52 citations
,
January 2001 in “Eye” This review discusses challenges in treating CMO associated with uveitis and highlights the need for prospective studies to guide therapy, as current treatments are largely empirical and potentially harmful.
51 citations
,
September 2008 in “Journal of Investigative Dermatology” This article reviews the role of vitamin D receptor in protecting the skin from UV radiation-induced damage and tumor formation, but it reports no new clinical results.
45 citations
,
September 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that deleting β-catenin in epidermis-specific VDR knockout mice did not prevent UVB-induced skin tumors, indicating β-catenin does not compensate for VDR's role in tumor suppression.
36 citations
,
March 2009 in “Molecular Carcinogenesis” This study found that Bcl-xL deficiency in mice increased apoptosis and resistance to skin tumor development, highlighting Bcl-xL's role in early skin carcinogenesis through anti-apoptotic functions.
35 citations
,
January 2006 in “Cancer Research” This study found that overexpressing PKCδ in transgenic mice did not reduce squamous cell carcinoma development induced by UV radiation, despite its effectiveness against TPA-promoted cancer in these mice.
32 citations
,
January 2016 in “Development” This study introduced Scd3-Cre mice, which enabled sebocyte-specific manipulation, revealing that sebaceous lipid depletion impaired water repulsion, thermoregulation, and the ocular surface, resembling Meibomian gland dysfunction.
31 citations
,
February 2019 in “International Journal of Cosmetic Science” This study found that ultraviolet radiation negatively affects hair follicle functions in human scalp skin, and caffeine application may provide some protective effects against this damage.
31 citations
,
January 2014 in “The Scientific World JOURNAL” This study found that the water extract of Eclipta prostrata L. may protect skin cells against UVB-induced damage, likely due to its antioxidant properties and absorption of UVA and UVB radiation.
31 citations
,
January 2011 in “Dermato-endocrinology” This review updates the protective effects and molecular mechanisms of melatonin against ultraviolet-induced damage in human skin, reporting no new clinical findings.
30 citations
,
November 1996 in “Archives of Dermatology” This report describes cases of increased hair loss and scalp sunburns in patients using 3% minoxidil and 0.01% tretinoin, suggesting caution with tretinoin use on sunny days.
30 citations
,
August 1984 in “Journal of the American Academy of Dermatology” This case report identified UVB photosensitivity and testicular failure as previously unreported components of low-sulfur hair syndrome in a 16-year-old male.
29 citations
,
September 1942 in “Archives of ophthalmology” This review discusses the Vogt-Koyanagi syndrome, highlighting its symptoms and historical context, but reports no new clinical findings; the authors emphasize its recognition as a distinct clinical entity.
24 citations
,
October 2008 in “PubMed” This article discusses how UV radiation affects hair protein and pigment, destructuralizes keratin, and emphasizes the protective role of melanin, but reports no new clinical results.
23 citations
,
May 2010 in “Surface and interface analysis” This study found that chemical treatments such as hair bleach and UV radiation significantly reduced the amount of 18-methyleicosanoic acid on the outer surface of human hair.
23 citations
,
March 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that extracellular ATP released from UVB-irradiated keratinocytes promotes melanin production through the P2X7 receptor, indicating a role for ATP-P2X7 signaling in UV-induced melanogenesis.
21 citations
,
January 2012 in “Biological and Pharmaceutical Bulletin” This study found that using a combination of iontophoresis and liposomal delivery facilitated the effective intradermal administration of superoxide dismutase in rats, reducing oxidative skin damage from UV exposure.
16 citations
,
October 2015 in “Photochemistry and photobiology” This study found that higher concentrations of copper (II) ions in human hair increase protein oxidative modification, contributing to hair damage regardless of UV exposure and pigmentation level.
15 citations
,
July 2022 in “Biomedicines” This study found that bioengineered skin substitutes developed for 21 or 28 days effectively mimic native skin's ability to absorb UV radiation, suggesting suitability for treating severe skin defects.
15 citations
,
February 2015 in “Han-gug chugsan sigpum hag-hoeji/Korean journal for food science of animal resources” This study concludes that egg shell membrane hydrolysates, particularly Fraction I, may effectively mitigate UV-B radiation-induced wrinkles and promote skin collagen and hyaluronic acid production, suggesting potential use in functional cosmetics.
14 citations
,
January 2005 in “Pediatric Dermatology” This case report describes a child with hypopigmented mycosis fungoides successfully treated with UVA1 light therapy.
11 citations
,
October 2022 in “Clinical Cosmetic and Investigational Dermatology” In this study, SNPs in genes affecting skin pigmentation were linked to each skin type's unique response to environmental stress, suggesting potential for personalized skin care products.
11 citations
,
March 2021 in “Molecular Carcinogenesis” This study found that deleting the transcription factor Twist1 in keratinocytes significantly reduced UVB-induced skin carcinogenesis in mice, suggesting a potential target for preventing cutaneous squamous cell carcinoma.