Optical Behavior of Human Skin Substitutes: Absorbance in the 200–400 nm UV Range

The study investigated the optical behavior of the UGRSKIN bioartificial skin substitute in the UV range, focusing on absorbance and transmittance over 28 days of ex vivo development. The bioartificial skin, made from human skin cells and fibrin-agarose biomaterials, showed a time-dependent maturation and differentiation of the epidermis, which expressed molecules capable of absorbing UV radiation. The absorbance patterns were similar to native skin, with values initially lower than control but surpassing them by 21 and 28 days. The findings suggested that the bioartificial skin at 21 or 28 days of development was suitable for clinical use due to its histological similarity to native skin and effective UV radiation absorbance.