Hypopigmented Mycosis Fungoides in a Child Successfully Treated with UVA1 Light

In 2005, a 9-year-old girl with hypopigmented mycosis fungoides was successfully treated with UVA1-light therapy. She initially had a hypopigmented, erythematous, and scaly patch in her left groin that did not respond to topical corticosteroids. A biopsy confirmed the diagnosis, revealing atypical lymphocytes and a monoclonal rearrangement of the T cell receptor gamma gene. After UVA1-light treatment, the patch size decreased, and the gene rearrangement became polyclonal. The patient achieved complete remission one year post-treatment and maintained normal skin appearance four years later. The document indicates that UVA1-light therapy may be effective for treating mycosis fungoides in children, as it induces apoptosis in T lymphocytes via reactive oxygen species.