Protein Kinase Cε Sensitizes Skin to UV Radiation-Induced Damage and Squamous Cell Carcinoma Development, Associates with Stat3

February 2007 in “ Cancer Research ”

Moammir Hasan Aziz, Herbert T. Manoharan, Ajit Kumar Verma

protein kinase Cε PKCε UV radiation squamous cell carcinoma Stat3 phosphorylation Stat3Ser727 Stat3Tyr705 transgenic mice photosensitizer UVR SCC

TLDR Protein Kinase Cε increases skin sensitivity to UV damage and skin cancer risk.

The study investigated the role of Protein Kinase Cε (PKCε) in increasing skin sensitivity to UV radiation and promoting squamous cell carcinoma (SCC) development through its interaction with the transcription factor Stat3. Using PKCε transgenic mice, researchers found that PKCε phosphorylated Stat3 at the Ser727 residue, enhancing its transcriptional activity and leading to increased expression of genes associated with cell proliferation and survival. The absence of PKCε in knockout mice reduced UV-induced Stat3 phosphorylation, underscoring PKCε's role as a Stat3Ser727 kinase. The findings suggested that targeting the PKCε-Stat3 interaction could be a potential therapeutic strategy for preventing UV-induced skin cancers.

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Research cited in this study

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research Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶

28 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may increase skin cancer risk by affecting nearby cells.

research Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.

79 citations , October 2003 in “PubMed”

research Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.

99 citations , February 2000 in “PubMed”

Overexpressing PKCepsilon in mice reduces papillomas but increases carcinomas.

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