Protein Kinase C Delta Overexpressing Transgenic Mice Are Resistant to Chemically but Not to UV Radiation-Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2

January 2006 in “ Cancer Research ”

Moammir Hasan Aziz, Deric L. Wheeler, Bhushan Bhamb, Ajit Kumar Verma

Protein Kinase C δ PKCδ squamous cell carcinoma SCC cytokines cyclooxygenase-2 COX-2 apoptosis UV radiation chemical carcinogens

Studysummary This study found that overexpressing PKCδ in transgenic mice did not reduce squamous cell carcinoma development induced by UV radiation, despite its effectiveness against TPA-promoted cancer in these mice.

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research Protein Kinase C Epsilon Signals Ultraviolet Light-Induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism

28 citations , January 2005 in “Photochemistry and Photobiology”

This study found that overexpression of PKCepsilon in mouse epidermis was associated with increased susceptibility to metastatic squamous cell carcinoma, potentially through a mechanism involving tumor necrosis factor-alpha.

research Protein Kinase C Epsilon Is Linked to 12-O-Tetradecanoylphorbol-13-Acetate-Induced Tumor Necrosis Factor-Alpha Ectodomain Shedding and the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase C Epsilon Transgenic Mice.

79 citations , October 2003 in “PubMed”

In this study, PKCepsilon transgenic mice showed increased TNFalpha shedding during skin tumor promotion, which may contribute to the development of metastatic squamous cell carcinoma.

research Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways

74 citations , September 2003 in “The Journal of Immunology”

This study found that PKCα activation in transgenic mice induces keratinocyte apoptosis and mediates neutrophilic skin inflammation via different pathways, suggesting potential mechanisms for cutaneous inflammatory diseases.

research Cyclooxygenase-2 Overexpression in the Skin of Transgenic Mice Results in Suppression of Tumor Development

113 citations , May 2002 in “PubMed”

This study observed that COX-2 overexpression in transgenic mice led to a significant reduction in skin tumor development compared to controls, challenging the expected role of COX-2 in promoting tumors.

research Transgenic Mice Overexpressing Protein Kinase C Epsilon in Their Epidermis Exhibit Reduced Papilloma Burden but Enhanced Carcinoma Formation After Tumor Promotion

99 citations , February 2000 in “PubMed”

This study found that overexpression of PKCepsilon in transgenic mice reduced papilloma development but accelerated carcinoma formation in a skin tumor promotion model.

research Overexpression of Protein Kinase C-α in the Epidermis of Transgenic Mice Results in Striking Alterations in Phorbol Ester-Induced Inflammation and COX-2, MIP-2, and TNF-α Expression but Not Tumor Promotion

135 citations , October 1999 in “Journal of Cell Science”

This study found that overexpression of PKCα in mouse epidermis increases expression of specific proinflammatory mediators and induces inflammation but does not significantly affect epidermal differentiation, proliferation, or tumor promotion with TPA.