Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶

January 2005 in “ Photochemistry and Photobiology ”

Deric L. Wheeler, Y. Li, Ajit Kumar Verma

Protein kinase C epsilon PKCepsilon ultraviolet radiation squamous cell carcinoma cytokines tumor necrosis factor-alpha TNFalpha paracrine mechanism skin carcinogenesis

TLDR Protein kinase C epsilon may increase skin cancer risk by affecting nearby cells.

The study investigated the role of Protein kinase C epsilon (PKCepsilon) in skin carcinogenesis using transgenic mice that overexpressed PKCepsilon. These mice showed increased sensitivity to developing metastatic squamous cell carcinoma (mSCC) when exposed to ultraviolet radiation or a tumor promotion protocol. The development of squamous cell carcinoma was linked to PKCepsilon-mediated induction of the cytokine tumor necrosis factor-alpha (TNFalpha). Interestingly, PKCepsilon was not expressed in the tumors themselves but was present in the surrounding uninvolved tissue, suggesting a paracrine mechanism. Similar patterns were observed in human squamous cell carcinoma, indicating that PKCepsilon overexpression in the epidermis may create a microenvironment conducive to mSCC development through specific cytokines.

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