In Human Skin, UVB Initiates Early Induction of IL-10 Over IL-12 Preferentially in the Expanding Dermal Monocytic/Macrophagic Population

July 1998 in “ Journal of Investigative Dermatology ”

Kefei Kang, Anita C. Gilliam, Guofen Chen, Elena Tootell, Kevin D. Cooper

UVB IL-10 IL-12 macrophages Langerhans cells CD11b+ monocytic/macrophagic population epidermis dermis immunosuppression skin immune cells interleukin-10 interleukin-12 CD11b+ monocytes

TLDR UVB exposure in human skin causes macrophages to produce more IL-10 and less IL-12, leading to immunosuppression.

The study demonstrated that after UVB exposure, differentiated macrophages in human skin produced high levels of IL-10 and low levels of IL-12, unlike Langerhans cells which produce IL-12. The first significant rise in IL-10 mRNA in the dermal CD11b+ monocytic/macrophagic population occurred 6 hours post-UV, peaking at 24-48 hours, and was followed by intense IL-10 production in the epidermis at 72 hours. This suggests that UV-induced changes in the dermal microenvironment activate these macrophages, leading to their migration to the epidermis. The findings highlighted the role of IL-10 in UV-induced immunosuppression and the dynamic changes in skin immune cell populations post-UV exposure.

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Research cited in this study

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research The Human Hair Follicle: A Reservoir of CD40+ B7-Deficient Langerhans Cells That Repopulate Epidermis After UVB Exposure

99 citations, April 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicles help skin immune recovery after UVB exposure.

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