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In this study, Brca1(S971A/S971A) mice showed a moderately increased risk of spontaneous tumor formation and defects in DNA damage response, suggesting CHK2 phosphorylation of BRCA1 is crucial for tumor suppression.

This communication reports previously unreported side effects, severe bullous dermatosis and onycholysis, in three patients undergoing high-dose methotrexate and leucovorin calcium therapy, impacting their chemotherapy schedules.

This study found that keratin damage in mammals and birds can result from N-homocysteinylation, reducing keratin solubility and indicating significant protein modification through genetic or nutritional disruptions in homocysteine metabolism.

This study found that the n-butanol extract from Untica mairei Levl's roots significantly inhibited 5α-reductase activity in an in vitro model using rat prostate enzyme.

In this study, researchers found that UV radiation causes hydroxy radicals to form cuticle holes specifically between the cuticle layers in wet hair, unlike random holes caused by Fenton's reaction.

This case study reports that an infant with maple syrup urine disease developed acrodermatitis dysmetabolica due to low isoleucine levels, and increasing the isoleucine dose improved the condition.

This study found that mice genetically modified to overexpress the serine protease inhibitor hurpin showed reduced UV-induced apoptosis but increased susceptibility to skin cancer after chemical carcinogenesis.

This study found that thioglycolic acid molecules in hair treatments are primarily located in intrafibrillar unordered areas, where they redistribute disulfide bonds.

This study found that the alkaline degradation process of hair keratin using nucleophilic reagents led to different proportions of reaction products compared to wool, particularly more lanthionine and lysinoalanine residues.

This case report details the diagnosis and management of argininosuccinate lyase deficiency in an infant, emphasizing initial symptoms, treatment strategies, and subsequent liver transplant leading to recovery.

This study suggests that a newly identified KRT 71 gene variant may be responsible for curly hair in Curly Coated Retrievers and potentially contributes to follicular dysplasia.

This case report describes a 40-year-old woman who developed erythema annulare centrifugum, a type of skin rash, likely triggered by taking the drug aceclofenac.

In this study, PKC ε transgenic mice exposed to ultraviolet radiation showed increased hair follicle stem cell frequency and altered gene expression compared to wild-type mice, suggesting a potential role in skin cancer susceptibility.

This study found that homocysteine-keratin accumulation in human hair increases towards the tips, linked to copper/iron-catalyzed demethylation of methionine, and may contribute to keratin damage.

This study identified a key Arabidopsis thaliana gene, TIP1, whose product is involved in S-acylation crucial for normal plant cell growth, particularly affecting root hair development.

This study found that mutations in type I IRS keratin genes disrupt keratin protein complexes in mice, suggesting crucial roles for these genes in proper hair coat formation.

This report suggests that TCDD may alter human epidermal stem cell populations by upregulating c-Myc, potentially leading to increased stem cell turnover during chloracne development.

In this study, a 68-year-old man with muscle-invasive bladder cancer and renal insufficiency achieved a partial radiological response to neoadjuvant therapy with gemcitabine and Disitamab Vedotin, without significant adverse events, highlighting a potential alternative for cisplatin-ineligible patients.

This review discusses the uses and toxicological data of eleven unsaturated halogenated hydrocarbons, including dichloroacetylene, allyl chloride, hexachlorobutadiene, β-chloroprene, vinyl chloride, trichloroethylene, and perchloroethylene, but presents no new findings.

This study found that sudden hair loss in guinea pigs may serve as a potential biomarker for subacute exposure to mustard gas, and pre-treatment with N-acetylcysteine could prevent this hair loss.

This study reports the discovery of mutations in the PADI3, TGM3, and TCHH genes as molecular genetic causes of uncombable hair syndrome in children, indicating an autosomal-recessive inheritance pattern.

In this randomized, placebo-controlled study, Kūlaris supplementation significantly improved quality of life for participants with mild-to-severe acne over 12 weeks, though no significant changes in general skin health measures were observed compared to placebo.

The researchers reported that silencing the NtNCED3-2 gene in tobacco reduced ABA content and drought tolerance, inhibited root and leaf development, and decreased photosynthetic ability due to altered isoprenoid metabolism.

The researchers reported that pulsed FUS can enhance the tumor-killing effects of cisplatin by unbinding it from albumin in cervical cancer, but further study is needed to measure its selective delivery to tumors.

A new genetic mutation causing Xeroderma Pigmentosum was found in an 8-year-old girl, affecting her DNA repair.

This study revealed that Vav2 and Vav3 play roles in regulating hair follicle bulge stem cells in normal conditions and cancer stem cell activation and remodeling in mice.

In this study, injecting chimeric RNA–DNA oligonucleotides into mice skin caused a temporary mutation in keratin 17, altering hair morphology, but the mutation was transient due to genetic compensation or cell replacement.