A Second KRT71 Allele in Curly Coated Dogs

November 2018 in “ Animal Genetics ”

Anina Bauer, Sheida Hadji Rasouliha, Magdalena A. T. Brunner, Vidhya Jagannathan, I. Bucher, Jeanette Bannoehr, Katarina Varjonen, R. Bond, Kerstin Bergvall, Monika Welle, Petra Roosje, Tosso Leeb

Studysummary This study suggests that a newly identified KRT 71 gene variant may be responsible for curly hair in Curly Coated Retrievers and potentially contributes to follicular dysplasia.

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research A Splice Variant in KRT71 Is Associated with Curly Coat Phenotype of Selkirk Rex Cats

40 citations , June 2013 in “Scientific Reports”

This study found an association between a splice site variant in the KRT71 gene and curly hair in Selkirk Rex cats, identifying a significant locus on chromosome B4.

research A Missense Mutation Within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis

78 citations , May 2012 in “Journal of Investigative Dermatology”

A specific gene mutation causes woolly hair and hair loss.

research The Naked Truth: Sphynx and Devon Rex Cat Breed Mutations in KRT71

75 citations , October 2010 in “Mammalian genome”

In this study, specific genetic polymorphisms in the KRT71 gene were associated with hairless and curly phenotypes in Sphynx and Devon Rex cats.

research Identification of the Rat Rex Mutation as a 7-Bp Deletion at Splicing Acceptor Site of the Krt71 Gene

45 citations , January 2010 in “Journal of Veterinary Medical Science”

This study identified a mutation in the keratin 71 gene that causes curly hair in certain rats, advancing our understanding of hair formation.

research Morphologic and Molecular Characterization of Two Novel Krt71 (Krt2-6g) Mutations: Krt71 Rco12 and Krt71 Rco13

51 citations , December 2006 in “Mammalian Genome”

research A Small Deletion Hotspot in the Type II Keratin Gene mK6irs1/Krt2-6g on Mouse Chromosome 15, a Candidate for Causing the Wavy Hair of the Caracul (Ca) Mutation

53 citations , October 2003 in “Genetics”

This study identified a mutation hotspot in the caracul (Ca) locus of mice, implicating the mK6irs1/Krt2-6g gene in hair formation and potentially human hair and skin diseases.

research Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency

42 citations , September 2003 in “Journal of Investigative Dermatology”

A missing mK6irs1 gene causes hair loss in mice.

research A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle

86 citations , May 2002 in “Journal of Investigative Dermatology”

This study characterized a new human keratin, hK6irs1, specifically found in the inner root sheath of hair follicles, which suggests its role in the structural integrity and guidance of growing hair shafts.

research A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

45 citations , March 2001 in “Journal of Investigative Dermatology”

This study identified a new cytokeratin, mK6irs, specifically expressed in the inner root sheath of mouse hair follicles, distinguishing it as a member of the type II cytokeratin family.