Safety and Clinical Efficacy of Kūlaris, an Herbal Supplement for Mild to Severe Acne Vulgaris: A 12-Week Randomized, Double-Blind, Placebo-Controlled Study

    September 2025 in “ Clinical Cosmetic and Investigational Dermatology ”
    Sudeep HV, Chandradhara Divya, Kodimule Shyamprasad
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    Studysummary In this randomized, placebo-controlled study, Kūlaris supplementation significantly improved quality of life for participants with mild-to-severe acne over 12 weeks, though no significant changes in general skin health measures were observed compared to placebo. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the efficacy and safety of Kūlaris, an herbal supplement, for treating mild to severe acne vulgaris in a 12-week randomized, double-blind, placebo-controlled trial involving 100 participants aged 18-40. Participants received either 450 mg of Kūlaris or a placebo daily. Results showed a significant improvement in quality of life for those taking Kūlaris, although no significant changes were observed in general skin health measures like skin quality, color, wrinkle reduction, and hydration. Kūlaris was well tolerated with no adverse effects reported, suggesting its potential as a therapeutic or adjunctive treatment for acne vulgaris.
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