Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies

May 2024 in “ International Journal of Molecular Sciences ”

Hyun Jee Kim, Yeong Ho Kim

acne vulgaris retinoids benzoyl peroxide antibiotics hormonal therapies laser therapy chemical peels biologics bacteriophages probiotics peptides Accutane Proactiv antibiotic treatments hormone therapy laser treatments chemical skin peels

TLDR Personalized acne treatments and new therapies show promise for better results.

The document reviews the multifaceted pathogenesis of acne and various treatment strategies, emphasizing the importance of personalized approaches. It discusses current treatments like topical retinoids, benzoyl peroxide, and antibiotics, as well as systemic options such as hormonal therapies and oral retinoids. Emerging therapies, including biologics, probiotics, and novel compounds like cannabidiol, show promise in clinical trials. The review highlights the role of the skin microbiome and environmental factors in acne development, advocating for a holistic treatment approach that integrates lifestyle considerations. Clascoterone, a novel topical antiandrogen, demonstrated significant efficacy in large-scale trials. The document underscores the need for further research into innovative therapies and the gut-skin axis to enhance acne management.

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research Guidelines of Care for the Management of Acne Vulgaris

5 citations , January 2024 in “Journal of the American Academy of Dermatology”

Use benzoyl peroxide, retinoids, antibiotics, and isotretinoin for acne, and combine treatments for better results.

research PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

9 citations , June 2023 in “Cells”

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

research Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

78 citations , June 2021 in “Dermatology and Therapy”

Future acne treatments should aggressively target inflammation to prevent scarring.

research Acne Vulgaris: New Evidence in Pathogenesis and Future Modalities of Treatment

33 citations , April 2021 in “Journal of Dermatological Treatment”

New ways to treat acne are being discovered.

Evaluation of Biophysical Skin Parameters and Hair Changes in Patients with Acne Vulgaris Treated with Isotretinoin, and the Effect of Biotin Use on These Parameters

research Evaluation of Biophysical Skin Parameters and Hair Changes in Patients with Acne Vulgaris Treated with Isotretinoin, and the Effect of Biotin Use on These Parameters

5 citations , March 2021 in “International Journal of Dermatology”

Biotin supplementation during isotretinoin treatment for acne may help maintain skin hydration and improve hair growth.

research Spironolactone and XPB: An Old Drug with a New Molecular Target

18 citations , May 2020 in “Biomolecules”

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

research Cannabinoid Signaling in the Skin: Therapeutic Potential of the Cutaneous Cannabinoid System

142 citations , March 2019 in “Molecules/Molecules online/Molecules annual”

Cannabinoids may help treat various skin conditions.

research Female Type of Adult Acne: Physiological and Psychological Considerations and Management

42 citations , September 2018 in “Journal der Deutschen Dermatologischen Gesellschaft”

Adult female acne requires a comprehensive treatment approach, including medical options and lifestyle changes, with attention to psychological well-being.

research The Use of Hormonal Antiandrogen Therapy in Female Patients with Acne: A 10-Year Retrospective Study

22 citations , March 2018 in “American Journal of Clinical Dermatology”

Hormonal antiandrogen therapy for acne is underused and can reduce the need for antibiotics.

research Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review

117 citations , February 2017 in “American Journal of Clinical Dermatology”

Oral spironolactone's effectiveness for adult female acne is not well-supported by strong evidence.

research Hormonal Treatment of Acne Vulgaris: An Update

46 citations , September 2016 in “Clinical, Cosmetic and Investigational Dermatology”

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

research Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

93 citations , January 2016 in “British Journal of Dermatology”

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

Mechanistic Target of Rapamycin (mTOR) Expression Is Increased in Acne Patients' Skin