TLDR Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.
The study investigated the role of Rho guanosine nucleotide exchange factors Vav2 and Vav3 in the regulation of skin stem cells (SSCs) under both normal and cancerous conditions using mouse models. The findings revealed that Vav2 and Vav3 are important in controlling the quantity, functional status, and responsiveness of hair follicle bulge stem cells. In normal SSCs, these factors are associated with gene expression programs that strengthen cell identity and maintain a quiescent state. Conversely, in cancer stem cells, Vav2 and Vav3 are linked to gene expression related to cell identity, activation, and cytoskeletal changes, highlighting their significant role in both normal and tumor epidermal stem cell regulation.
4 citations,
January 2020 in “Cells” The research found that the gene activity in mouse skin stem cells changes significantly as they age.
22 citations,
June 2013 in “International journal of molecular sciences” Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.
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September 2011 in “Cell stem cell” Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.
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September 2023 in “Frontiers in cell and developmental biology” Vav2 changes how hair follicle stem cells' genes work as they age, which might improve regeneration but also raise cancer risk.
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