The Rho Guanosine Nucleotide Exchange Factors Vav2 And Vav3 Modulate Epidermal Stem Cell Function

    May 2022 in “ Oncogene ”
    L. Francisco Lorenzo‐Martín, Mauricio Menacho-Márquez, Natalia Fernández-Parejo, Sonia Rodríguez-Fdez, Gloria Pascual, Antonio Abad, Piero Crespo, Mercedes Dosil, Salvador Aznar Benitah, Xosé R. Bustelo
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    TLDR Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.
    The study investigated the role of Rho guanosine nucleotide exchange factors Vav2 and Vav3 in the regulation of skin stem cells (SSCs) under both normal and cancerous conditions using mouse models. The findings revealed that Vav2 and Vav3 are important in controlling the quantity, functional status, and responsiveness of hair follicle bulge stem cells. In normal SSCs, these factors are associated with gene expression programs that strengthen cell identity and maintain a quiescent state. Conversely, in cancer stem cells, Vav2 and Vav3 are linked to gene expression related to cell identity, activation, and cytoskeletal changes, highlighting their significant role in both normal and tumor epidermal stem cell regulation.
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