Expression of the Human Cathepsin L Inhibitor Hurpin in Mice: Skin Alterations and Increased Carcinogenesis

    August 2007 in “ Experimental Dermatology ”
    Markus Walz, Sabine Kellermann, Matilda Bylaitė … Thomas Ruzicka
    Studysummary This study found that mice genetically modified to overexpress the serine protease inhibitor hurpin showed reduced UV-induced apoptosis but increased susceptibility to skin cancer after chemical carcinogenesis.
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    Research cited in this study 3

    1. Matriptase/MT-SP1 Is Required for Postnatal Survival, Epidermal Barrier Function, Hair Follicle Development, and Thymic Homeostasis Oncogene · 2002
    2. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002
    3. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002