RNA Interference of NtNCED3 Reduces Drought Tolerance and Impairs Plant Growth Through Feedback Regulation of Isoprenoids in Nicotiana Tabacum

July 2018 in “ Environmental and Experimental Botany ”

Yongxia Yang, Qianqian Zhou, Jiayang Xu, Qingchang Li, Songtao Zhang

RNA interference NtNCED3 abscisic acid ABA drought tolerance isoprenoids Nicotiana tabacum tobacco root hair growth trichome development photosynthetic pigments diterpenoids

TLDR Silencing NtNCED3-2 gene in tobacco reduces drought tolerance and impairs growth.

The study isolated two variants of the NCED3 gene (NtNCED3-1 and NtNCED3-2) from tobacco and found that silencing NtNCED3-2 reduced abscisic acid (ABA) content, drought tolerance, and impaired plant growth. Specifically, suppression of NtNCED3-2 inhibited primary root development, root hair growth, and trichome development, and decreased photosynthetic ability by reducing diterpenoids and photosynthetic pigments. The findings indicated that NtNCED3-2 plays a crucial role in ABA-mediated feedback regulation of isoprenoid metabolism, which is essential for plant growth and stress response.

View this study on sciencedirect.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 29 results

community Any updates on GT20029? Phase 2 results were supposed to be out by the end of Q1 2024. What happened ?

in Product 20 upvotes 8 months ago

The conversation is about the anticipation and uncertainty regarding the release of GT20029 Phase 2 results for hair loss treatment. Users express hope for its effectiveness and minimal side effects compared to other treatments like Pyri and HMI115.

community Does CosmeRNA target the root cause of MPB?

in Chat 1 year ago

. CumsOnYourFeet69 has been discussing a new treatment called CosmeRNA which claims to target the root cause of male pattern baldness, and is considering using it in conjunction with Minoxidil instead of Finasteride due to possible side effects. Replies have highlighted that the efficacy of this treatment is still unknown, but it could be used as an effective maintenance option if successful.

community Since there is so much hype for cosmeRNA and HMI-115...

in Chat 47 upvotes 1 year ago

Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

community The Korean began to suspect something. But they understood the mechanism to some extent. ( Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor)

in Research 86 upvotes 3 weeks ago

Cold shock therapy may promote hair growth by stimulating follicular muscles and affecting stem cells. The exact mechanisms and full range of elements involved are not yet fully understood.

community Finally about to start Pyriltamide (ONLY Pyriltamide)

in Chat 63 upvotes 4 months ago

A user is excited to start using Pyriltamide for hair loss after experiencing side effects from topical finasteride. Other users discuss the potential and skepticism of Pyriltamide compared to older treatments like finasteride and RU58841.

community How do we only have two treatments to combat hair loss at this point in time?

in Chat 211 upvotes 1 year ago

The post discusses frustration over the limited and not always effective treatments for hair loss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.

Similar Research

5 / 1000+ results

research Keratin Disorders: From Gene to Therapy

109 citations, September 2011 in “Human molecular genetics online/Human molecular genetics”

New treatments targeting specific genes show promise for treating keratin disorders.

research Phospholipase A2 Is Required for PIN-FORMED Protein Trafficking to the Plasma Membrane in the Arabidopsis Root

84 citations, June 2010 in “The Plant Cell”

Phospholipase A2 is necessary for the correct placement of PIN proteins in plant roots, affecting root growth.