Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice

    September 2018 in “ International journal of genomics
    Kamila Borowczyk, Jacek Wróblewski, Joanna Suliburska … Hieronim Jakubowski
    Studysummary This study found that keratin damage in mammals and birds can result from N-homocysteinylation, reducing keratin solubility and indicating significant protein modification through genetic or nutritional disruptions in homocysteine metabolism.
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    1. Demethylation of Methionine and Keratin Damage in Human Hair Amino acids · 2018

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    1. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins Journal of Investigative Dermatology · 1989