Evaluation of Serum Homocysteine Levels in Patients with Cutaneous-Oral Lichen Planus and Psoriasis

In a study conducted in 2015, researchers evaluated serum homocysteine, vitamin B12, and folic acid levels in 30 patients with psoriasis and 30 patients with cutaneous-oral lichen planus. They found that 30% of the psoriasis group and 36.66% of the cutaneous-oral lichen planus group had abnormally high blood homocysteine levels. The psoriatic group had significantly higher serum vitamin B12 levels compared to the cutaneous-oral lichen planus group, while the difference in serum folic acid levels between the two groups was not significant. The study concluded that both patient groups had higher serum homocysteine levels than healthy controls, suggesting a need for further research on treatment courses for these conditions before therapeutic intervention.