The Pharmacology of Methotrexate
August 1991
in “
Journal of The American Academy of Dermatology
”
methotrexate dihydrofolate reductase polyglutamates leucovorin psoriasis alopecia hepatotoxicity renal failure pulmonary toxicity neurotoxicity teratogenic effects immunosuppressive effects MTX folic acid antagonist folate analog folinic acid hair loss liver toxicity kidney failure lung toxicity nerve toxicity birth defects immune suppression
Studysummary This article reviews methotrexate's pharmacokinetics and toxicity, emphasizing the role of urinary excretion and leucovorin in avoiding most toxic reactions; it provides no new clinical results.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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