TLDR Methotrexate is effective and well-tolerated in children for certain skin conditions but requires careful monitoring.
The review discussed the use of methotrexate (MTX) in treating various pediatric dermatoses, highlighting its cost-effectiveness and safety profile. MTX showed efficacy in conditions like psoriasis, atopic dermatitis, localized scleroderma, and juvenile dermatomyositis, with significant improvement in severe psoriasis cases and comparable results to cyclosporine in atopic dermatitis. Its efficacy in alopecia areata was variable. MTX was well-tolerated with manageable side effects, making it a viable option for pediatric dermatologic conditions. The review also debated the role of liver biopsy in monitoring MTX therapy, suggesting serum type III pro-collagen aminopeptide (PIIINP) as a potential alternative.
39 citations,
January 2012 in “Dermatology” Combining high-dose corticosteroids with methotrexate may be effective and safe for severe alopecia areata.
70 citations,
April 2011 in “British journal of dermatology/British journal of dermatology, Supplement” Methotrexate sometimes helps regrow hair in children with severe alopecia areata and is generally safe.
25 citations,
January 2005 in “Pediatric Dermatology” Methotrexate effectively treated a 2-year-old's generalized pustular psoriasis without side effects.
97 citations,
January 1999 in “International Journal of Dermatology” Pityriasis rubra pilaris is a rare skin disorder with reddish-orange patches and thickened skin, needing better treatment understanding.
155 citations,
August 1991 in “Journal of The American Academy of Dermatology” Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.
59 citations,
June 2022 in “Frontiers in medicine” There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
48 citations,
January 2015 in “Indian Journal of Dermatology, Venereology and Leprology” Vitamin D is important for skin health and can help treat psoriasis, atopic dermatitis, and vitiligo.
January 2024 in “Journal der Deutschen Dermatologischen Gesellschaft” Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.
November 2019 in “Harper's Textbook of Pediatric Dermatology” The document is a detailed medical reference on skin and genetic disorders.
5 citations,
January 2016 in “Journal of The American Academy of Dermatology” Skin doctors should know about skin and kidney disease links to prevent serious kidney problems.
