TLDR Methotrexate is not proven to maintain remission in ulcerative colitis.
The document reviewed the efficacy of methotrexate for maintaining remission in ulcerative colitis. It included data from several trials with a total of 165 patients, comparing methotrexate to placebo and other treatments like sulfasalazine, 6-mercaptopurine, and 5-aminosalicylic acid. The results showed no significant differences in remission maintenance, with the evidence quality rated as low to very low due to small sample sizes and high risk of bias. Adverse events such as leucopenia, migraine, nausea, and mild alopecia were reported. The review concluded that there was insufficient evidence to support the use of methotrexate for this purpose and recommended further large-scale, methodologically rigorous trials.
51 citations,
August 2015 in “Cochrane library” Methotrexate is not proven to maintain remission in ulcerative colitis.
53 citations,
August 2014 in “Cochrane library” Methotrexate is not proven effective for inducing remission in ulcerative colitis.
53 citations,
August 2014 in “Cochrane library” Methotrexate is not proven effective for inducing remission in ulcerative colitis.
18 citations,
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August 2014 in “Cochrane library” Budesonide is not effective for maintaining remission in Crohn's disease beyond three months.
