Cardiovascular Risk Markers and Thyroid Status in Young Indian Women with Polycystic Ovarian Syndrome: A Case-Control Study

    April 2014 in “ Journal of Obstetrics and Gynaecology Research ”
    Perla Sravan Kumar, Palghat Hariharan Ananthanarayanan, Soundravally Rajendiran
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    TLDR Young Indian women with PCOS have a higher risk of heart disease, not linked to thyroid function but to higher levels of certain fats and homocysteine.
    The study investigated the association between cardiovascular risk markers, thyroid function, and polycystic ovarian syndrome (PCOS) in 30 young Indian women with PCOS and 30 age-matched controls. Thyroid function tests were normal in both groups, but women with PCOS had significantly higher levels of total cholesterol, triglycerides, LDL-C, VLDL-C, homocysteine, and lipoprotein(a) compared to controls. Married women with PCOS had higher levels of these markers than unmarried women. The study concluded that women with PCOS are at an increased risk of cardiovascular diseases, which is not related to thyroid status but may be due to elevated levels of certain lipids and homocysteine. The study suggests the need for future research to further understand the link between dyslipidemia and cardiovascular risk in PCOS.
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