Comparison of Metformin and N-Acetylcysteine on Metabolic Parameters in Women with Polycystic Ovarian Syndrome

    June 2017 in “ International journal of reproduction, contraception, obstetrics and gynecology ”
    Hina Ali, Gita Radhakrishnan, Alpana Singh
    Image of study
    TLDR N-acetylcysteine was more effective and had fewer side effects than metformin for improving insulin resistance in women with PCOS.
    In a study involving 106 women with polycystic ovarian syndrome (PCOS), the effects of metformin (MET) and N-acetylcysteine (NAC) on metabolic parameters were compared. Both treatments significantly improved insulin resistance and metabolic syndrome, but NAC was found to be more effective in improving insulin resistance parameters such as HOMA-IR and in reducing triglycerides, LDL, VLDL, and testosterone levels, while also increasing HDL. Additionally, NAC treatment resulted in fewer side effects, with only 5% of participants reporting issues compared to 26.5% in the MET group. The study concluded that NAC may be a better long-term therapy option for PCOS patients due to its efficacy and minimal side effects.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 36 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  828 upvotes 5 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community C’est terrible - at my wits end

      in Female  442 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community One+ year 1mg Fin, Ketoconazole, and 3.75 Oral Min. I have DUPA. Switched from Topical to Oral Min.

      in Progress Pictures  142 upvotes 2 years ago
      A user's experience with hair loss treatments such as finasteride, ketoconazole, and oral minoxidil that have not yielded any results; other users suggest shaving the head or getting a wig, while others offer additional advice such as seeing a dermatologist, checking thyroid levels, switching to dutasteride and adding needling, and trying stemoxydine.
      [object Object]

      community Topical rapamycin, metformin, a-kg grow hair

      in Research/Science  14 upvotes 4 years ago
      The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

      community Finasteride and Metformin together?

      in Finasteride/Dutasteride  1 upvotes 1 year ago
      The conversation is about whether it's safe to take Metformin for weight loss and Finasteride together, with the concern that Finasteride is not commonly used for hair loss treatment in the user's location, and their doctor is not knowledgeable about it.

    Similar Research

    5 / 1000+ results