Free Androgen Index's Relations with Oxidative Stress and Insulin Resistance in Polycystic Ovary Syndrome

March 2023 in “ Scientific Reports ”

Leili Rahmatnezhad, Lida Moghaddam‐Banaem, Tahereh Behroozi-Lak, Afshin Shiva, Javad Rasuli

free androgen index oxidative stress insulin resistance polycystic ovary syndrome malondialdehyde FAI PCOS MDA

TLDR Oxidative stress, not insulin resistance, is significantly related to free androgen index in PCOS.

This study investigated the relationship between the free androgen index (FAI), oxidative stress, and insulin resistance in 160 women with polycystic ovary syndrome (PCOS) in Iran. The study found that 18.75% of participants had high FAI, with phenotype C showing the highest levels. Insulin resistance was present in 74.4% of participants, but it was not statistically associated with FAI. However, PCOS phenotypes and malondialdehyde (MDA) levels, an indicator of oxidative stress, were significantly related to FAI. The study highlights the importance of oxidative stress in relation to FAI in PCOS, rather than insulin resistance.

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6 / 6 results

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