TLDR Oxidative stress, not insulin resistance, is significantly related to free androgen index in PCOS.
This study investigated the relationship between the free androgen index (FAI), oxidative stress, and insulin resistance in 160 women with polycystic ovary syndrome (PCOS) in Iran. The study found that 18.75% of participants had high FAI, with phenotype C showing the highest levels. Insulin resistance was present in 74.4% of participants, but it was not statistically associated with FAI. However, PCOS phenotypes and malondialdehyde (MDA) levels, an indicator of oxidative stress, were significantly related to FAI. The study highlights the importance of oxidative stress in relation to FAI in PCOS, rather than insulin resistance.
63 citations
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May 2019 in “Hormone and Metabolic Research” Selenium might help with insulin resistance and cholesterol in PCOS, but more research is needed to confirm its benefits.
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May 2010 in “Current Women's Health Reviews” Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.
195 citations
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November 2019 in “Clinica Chimica Acta” High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.
