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This review highlights recent advancements in engineered probiotics for wound healing, reporting that genetically engineered strains of Lactobacillus reuteri and Lactococcus cremoris have shown promise in promoting faster wound healing in pre-clinical and clinical settings, particularly for diabetic foot ulcers.

This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.

In three patients with diabetic ulcers, this study reported remarkable wound healing and tissue regeneration after 3 to 6 weekly applications of growth factors-rich plasma and membrane treatment.

In this study, cryopreserved fibroblast cell sheets cultured on a new substrate showed significantly enhanced healing of cutaneous ulcers in diabetic and immunodeficient mice, suggesting potential effectiveness for refractory skin wounds.

This study reports that negative pressure wound therapy combined with PRP may effectively accelerate wound healing and reduce mortality in diabetic foot ulcers, with albumin and age identified as independent predictors of mortality risk.

In this review, the authors discuss the promising role of exosomes from various cell sources as potential cell-free therapies for diabetic foot ulcers, highlighting their therapeutic benefits in wound healing and the challenges faced in their clinical application.

This review highlights that the RNA modification N⁶-methyladenosine (m⁶A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.

This report describes a case where applying fresh aloe vera leaf to roentgen dermatitis resulted in significant skin healing and reduced itching within five weeks.

This study highlights the crucial, multifaceted roles of fibroblasts in wound healing and various diseases, including their dysregulation in diabetic foot ulcers, underscoring the need for targeted therapies to address complications and morbidity from such chronic conditions.

This study found that combining Panax notoginseng saponins with bone mesenchymal stem cells significantly enhanced diabetic cutaneous ulcer healing in rats by reducing inflammation and promoting new epidermis formation through specific molecular pathways.

This study found that autologous micro-grafts improved wound healing and reduced pain in leg ulcers unresponsive to routine treatments within one week, lasting up to a month.

This review discusses advancements in stem cell therapies for treating diabetic foot ulcers but reports no new clinical results; the authors emphasize the potential of regenerative techniques and call for further research to enhance wound healing mechanisms.

This study observed that in patients with diabetic foot ulcers, an imbalance in skin microbiota, with increased pathogenic bacteria, contributes to infection and poor wound healing, and suggests that modulating microbiota composition might improve healing outcomes.

This study suggests that activating the PPARs/SHH-mitochondrial axis may enhance diabetic wound healing by improving endothelial cell metabolism and angiogenesis, indicating potential for PPAR agonists in treating diabetic foot ulcers.

This systematic review suggests that stem cell-based therapies may offer potential benefits for healing pure venous ulcers, but findings are preliminary due to small sample sizes and varied interventions.

In this study, researchers found that gentamicin-loaded exosomes derived from a bovine leukocyte spleen extract significantly enhanced antimicrobial activity and tissue regeneration in infected diabetic wounds, showing potential as an effective therapeutic strategy for diabetic foot ulcers by improving infection control and promoting healing.

This review examines the potential of biomaterial-based wound dressings in managing diabetic foot ulcers, highlighting their versatility and therapeutic properties for promoting wound healing in individuals with diabetes mellitus.

This study found that a hydrogel made from human placenta-derived ECM, copper, and endothelial progenitor cells significantly enhanced pressure ulcer healing in a mouse model by improving wound closure and tissue regeneration.

This study found that implanting hair-follicle-associated pluripotent stem cell sheets facilitated wound healing and early macrophage activity while reducing inflammation in a diabetic mouse model, suggesting clinical potential for difficult-to-heal diabetic ulcers.

This narrative review examines the structure-function relationship in bioactive biopolymers used to promote healing in chronic wounds, emphasizing diabetic ulcers, and underscores the importance of characterizing these biopolymers to enhance their bioactivity for better tissue regeneration outcomes.

This study found that gentamicin-loaded exosomes derived from bovine leukocyte spleen extract enhanced antimicrobial activity and promoted tissue regeneration in infected diabetic mouse wounds, suggesting a potential innovative therapeutic strategy for diabetic foot ulcers by combining infection control with pro-regenerative and immunomodulatory effects.

In this study, gentamicin-loaded exosomes from a bovine leukocyte spleen extract were found to enhance tissue regeneration and antimicrobial activity, offering a promising therapeutic approach for infected diabetic foot ulcers by promoting wound healing and modulating inflammation in a diabetic mouse model.

This study found that the meropenem-loaded spanlastic formulation showed strong potential as an effective topical therapy for bacterial skin infections in non-diabetic mice, demonstrating superior therapeutic activity and wound healing compared to free meropenem.

In this study, conditioned medium from genetically engineered mesenchymal stem cells significantly improved wound healing, re-epithelialization, hair follicle formation, and angiogenesis in diabetic mice, suggesting a promising new approach for diabetic ulcer care.

This study found that both single and double spin platelet-rich plasma methods significantly reduced chronic ulcer surface area, with single spin showing notable healing improvements.

This report describes almost complete resolution of calcinosis and healing of associated ulcers in an 83-year-old woman with localized scleroderma after repeated intralesional steroid injections.

This article discusses the development of consensus-based guidelines for preventing lower extremity arterial insufficiency ulcers but reports no new clinical results.

This case report describes successful wound healing in a patient with chronic gout and tophaceous ulcers following platelet-rich plasma therapy, highlighting its potential effectiveness in treating non-healing wounds.

This study found that skin bacteria promote regeneration in wound-induced hair follicle neogenesis, suggesting a role for IL-1β signaling and challenging the belief that infection inhibits healing.

In this case report, a 66-year-old woman with rheumatoid arthritis developed cutaneous ulceration attributed to leflunomide treatment, which significantly healed after discontinuing the drug and administering cholestyramine, underscoring the need for careful monitoring of leflunomide's adverse effects.