Gentamicin-Loaded Exosomes From Immunepotent CRP Enhance Healing Of Infected Diabetic Wounds In Mice
November 2025
in “
OPAL (Open@LaTrobe) (La Trobe University)
”
TLDR Gentamicin-loaded exosomes improve healing of infected diabetic wounds in mice.
The study investigates the use of gentamicin-loaded exosomes derived from IMMUNEPOTENT CRP to treat infected diabetic wounds in mice. The results show that these exosomes significantly enhance collagen deposition, blood vessel formation, and hair follicle regeneration, while also modulating the inflammatory response by reducing pro-inflammatory cytokines and increasing anti-inflammatory IL-10. This suggests that gentamicin-loaded exosomes could be an effective and less invasive treatment for diabetic foot ulcers, offering both infection control and regenerative benefits.