Gentamicin-Loaded Exosomes From Immunepotent CRP Enhance Healing Of Infected Diabetic Wounds In Mice

    November 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Paola Leonor García Coronado (18582106), Brandon Alberto Garza Martínez (22695917), Kenia Arisbe Moreno Amador (22695920), David Reding Hernández (22695923), Diana G. Zárate Triviño (22695926), Diana Elia Caballero Hernández (22695929), Pablo Zapata Benavides (18582121), Gabriel Luna Barcenas (22695932), Cristina Rodríguez‐Padilla (22695935), Moisés Armides Franco Molina (18582109)
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    Studysummary In this study, gentamicin-loaded exosomes from a bovine leukocyte spleen extract were found to enhance tissue regeneration and antimicrobial activity, offering a promising therapeutic approach for infected diabetic foot ulcers by promoting wound healing and modulating inflammation in a diabetic mouse model.
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    The study investigates the use of gentamicin-loaded exosomes derived from IMMUNEPOTENT CRP to treat infected diabetic wounds in mice. The results show that these exosomes significantly enhance collagen deposition, blood vessel formation, and hair follicle regeneration, while also modulating the inflammatory response by reducing pro-inflammatory cytokines and increasing anti-inflammatory IL-10. This suggests that gentamicin-loaded exosomes could be an effective and less invasive treatment for diabetic foot ulcers, offering both infection control and regenerative benefits.
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