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Glossary Gentamicin

antibiotic treating bacterial infections by inhibiting protein synthesis

Gentamicin, also known as Garamycin, is an antibiotic used to treat a variety of bacterial infections, particularly those caused by Gram-negative bacteria. It works by inhibiting protein synthesis in bacteria, leading to their death. This medication is often administered intravenously or intramuscularly and is commonly used in hospital settings for severe infections.

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research Successful Topical Treatment of Murine Cutaneous Leishmaniasis with a Combination of Paromomycin (Aminosidine) and Gentamicin

65 citations , April 1999 in “Journal of Parasitology”

This study found that all lesions in mice treated with a new topical formulation, WR 279,396, healed completely without relapse, outperforming other formulations and showing no toxicity.

research Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo

26 citations , September 2014 in “Neuroscience Letters”

This study found that metformin did not prevent gentamicin-induced hearing loss and even worsened auditory threshold shifts and caused adverse effects at higher doses in guinea pigs.

research DETERMINATION OF PERMEATION PATHWAY OF GENTAMICIN INTO PIGâ€™S EAR SKIN

3 citations , April 2015 in “International research journal of pharmacy”

This study concluded that the follicular route is a significant pathway for delivering gentamicin through the skin, as demonstrated by higher drug permeation in non-plugged pig's ear skin compared to plugged skin.

research Autophagy-related protein 12 associates with anti-apoptotic B cell lymphoma-2 to promote apoptosis in gentamicin-induced inner ear hair cell loss

2 citations , April 2017 in “Molecular Medicine Reports”

In this study, blocking autophagy with 3-methyladenine significantly improved the survival of inner ear hair cells in a gentamicin-induced ototoxic mouse model.

research Effect of low level laser therapy on hair cell regeneration following gentamicin induced ototoxicity in postnatal organotypic culture of rat cochlea

1 citations , February 2010 in “Proceedings of SPIE”

This study suggests that low level laser therapy may promote hair cell regeneration in rat cochlear explants following gentamicin-induced damage.

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