Risk Factors for Diabetic Foot Ulcers Mortality and Novel Negative Pressure Combined with Platelet-Rich Plasma Therapy in the Treatment of Diabetic Foot Ulcers

    December 2022 in “ Frontiers in Pharmacology ”
    Yanling Wang, Bang Liu, Yinzhen Pi, Li Hu, Yeling Yuan, Jiao Luo, Yixiao Tao, Ping Li, Shan Lu, Wei Song
    TLDR Combining negative pressure therapy with platelet-rich plasma speeds up healing and lowers death risk in diabetic foot ulcers.
    The study examined risk factors for diabetic foot ulcer (DFU) mortality and assessed the effectiveness of combining negative pressure wound therapy (NPWT) with platelet-rich plasma (PRP) in treating DFUs. It involved 1,163 patients, with 653 having DFUs, and identified advanced age and low albumin levels as key mortality risk factors. In a treatment comparison of 31 DFU patients, the NPWT and PRP combination significantly improved healing rates (93.8% vs. 53.3%) and reduced mortality (6.3% vs. 40%) compared to NPWT with standard dressing. The results suggest that NPWT combined with PRP is more effective in accelerating ulcer healing and reducing mortality in DFU patients.
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