Leflunomide-Induced Cutaneous Ulcers: A Rare Diagnostic Conundrum

In this case report, discontinuing leflunomide resolved chronic cutaneous ulcers in a 67-year-old woman, suggesting a potential link between long-term leflunomide use and ulcer formation.

This case report describes a 43-year-old woman diagnosed with both Kikuchi-Fujimoto disease and systemic lupus erythematosus, who showed clinical improvement after treatment with glucocorticoids and hydroxychloroquine, highlighting the rare coexistence of these conditions and the ongoing uncertainty about the precise cause of Kikuchi-Fujimoto disease.

In this case report, a rare form of chronic cutaneous lupus, lupus erythematosus profundus, was treated effectively with topical and systemic therapies, leading to improvement and healing of ulcerations, though resulting in atrophic scars and macules.

This case report presents a rare instance of coexistent tumid lupus erythematosus and systemic lupus erythematosus in a patient, with symptom improvement noted after hydroxychloroquine treatment.

This case report highlights the diagnostic challenges in a patient with atypical lupus erythematosus tumidus due to long-term misdiagnosis and conflicting pathological findings, with effective treatment achieved using hydroxychloroquine and methylprednisolone.