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    Did you mean Tumor Suppressor Gene?
    Glossary Tumor Suppressor Gene

    regulates cell growth by preventing uncontrolled cell division

    A tumor suppressor gene is a type of gene that helps regulate cell growth by preventing cells from dividing too quickly or in an uncontrolled way. When these genes are mutated or inactivated, it can lead to the development of cancer because the normal checks on cell division are lost. Examples include the TP53 gene, which produces a protein that can trigger cell death if DNA damage is detected, thereby preventing the propagation of potentially cancerous cells.

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    1. Epigenetic regulation in adult stem cells and cancers Cell & Bioscience · 2013 · 20 citations
    2. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis Journal of Investigative Dermatology · 2015 · 19 citations
    3. Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis Journal of Investigative Dermatology · 2004 · 10 citations
    4. The Tumor Suppressor Actions of the Vitamin D Receptor in Skin 2014 · 9 citations
    5. Removing all obstacles: A critical role for p53 in promoting tissue renewal Cell Cycle · 2010 · 30 citations
    6. The role of <i>Atg5</i> gene in tumorigenesis under autophagy deficiency conditions The Kaohsiung Journal of Medical Sciences · 2024 · 4 citations
    7. Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion PloS one · 2012 · 72 citations
    8. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment GenomeBiology.com · 2015 · 153 citations
    9. K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors Scientific Reports · 2021 · 4 citations
    10. Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle Science · 2026
    11. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters Experimental Dermatology · 2016 · 6 citations
    12. Roles of tumor suppressors in regulating tumor-associated inflammation Cell Death & Differentiation · 2014 · 44 citations
    13. The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor Tumor Biology · 2021 · 16 citations
    14. Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells Scientific Reports · 2023 · 2 citations
    15. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000 · 215 citations
    16. Development of Heritable Melanoma in Transgenic Mice Journal of Investigative Dermatology · 1998 · 75 citations
    17. Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation BMC Cancer · 2011 · 7 citations
    18. Disruption of tubular Flcn expression as a mouse model for renal tumor induction Kidney International · 2015 · 29 citations
    19. Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB Planta Medica · 2008 · 54 citations
    20. Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo PLoS ONE · 2025
    21. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    22. SASH1 Mutations and Hereditary Disorders of Pigmentation: Review of Literature Pigment Cell & Melanoma Research · 2025 · 1 citations
    23. New insights into the role of Runx1 in epithelial stem cell biology and pathology Journal of Cellular Biochemistry · 2012 · 63 citations
    24. Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma EBioMedicine · 2021 · 7 citations
    25. Mediator1: An Important Intermediary of Vitamin D Receptor–Regulated Epidermal Function and Hair Follicle Biology Journal of Investigative Dermatology · 2012 · 5 citations
    26. The Paradox of p53: What, How, and Why? Cold Spring Harbor Perspectives in Medicine · 2016 · 64 citations
    27. Molecular Regulation of Melanocyte Senescence Pigment Cell Research · 2002 · 85 citations
    28. KRT17 promotes endometrial cancer cell migration as well as angiogenesis by regulating HIF-1α/VEGF pathway European journal of gynaecological oncology · 2023
    29. Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways American Journal Of Pathology · 2009 · 45 citations
    30. 14. Wound Healing; Cutaneous Therapy; Hair Medical & surgical dermatology · 2008