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    Glossary Topical Melatonin

    hormone applied to skin to promote hair growth

    Topical melatonin refers to the application of melatonin directly onto the skin, typically in the form of creams, gels, or serums. Melatonin, a hormone primarily known for regulating sleep, has antioxidant properties and can help protect skin cells from damage. In the context of hair and alopecia, topical melatonin is being explored for its potential to promote hair growth and reduce hair loss by protecting hair follicles from oxidative stress.

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    1. Topical Melatonin for Treatment of Androgenetic Alopecia International Journal of Trichology · 2012 · 39 citations
    2. The impact of body site, topical melatonin and brushing on hair regrowth after clipping normal Siberian Husky dogs Veterinary Dermatology · 2006 · 17 citations
    3. Topical Melatonin in Androgenetic Alopecia: Mechanisms of Action and Current Clinical Evidence Journal of Independent Medicine · 2026
    4. Topical Melatonin in Aesthetic Dermatology: From Cutaneous Melatoninergic Biology to Photoprotection, and Skin Rejuvenation Clinics in Dermatology · 2026
    5. Topical Melatonin in the Treatment of Hair Loss (Alopecia): A Comprehensive Scientific Review DOAJ (DOAJ: Directory of Open Access Journals) · 2026
    6. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    7. Topical Melatonin and Hair Graying Repigmentation: a Case Series Dermatology Practical & Conceptual · 2026
    8. Topical melatonin has a beneficial effect on hair growth in women with diffuse or androgenetic alopecia, Inpharma Weekly · 2004
    9. Topical application of synthetic melanin promotes tissue repair npj Regenerative Medicine · 2023 · 19 citations
    10. Efficacy and safety of topical rosuvastatin & melatonin vs. placebo in patients with mild to moderate plaque psoriasis: A preliminary randomized double‐blinded clinical trial Skin research and technology · 2024 · 1 citations
    11. Clinical Studies Using Topical Melatonin International journal of molecular sciences · 2024
    12. Melatonin and hair physiology: reasons and clinical efficacy data as a topical treatment of androgenic alopecia Medicina cutánea ibero-latino-americana · 2014
    13. Protective Effects of Melatonin on the Skin: Future Perspectives International Journal of Molecular Sciences · 2019 · 44 citations
    14. Protective Role of Melatonin and Its Metabolites in Skin Aging International Journal of Molecular Sciences · 2022 · 32 citations
    15. Melatonin in der topischen Behandlung der androgenetischen Alopezie Aktuelle Dermatologie · 2011 · 4 citations
    16. Beyond Circadian Rhythm: Melatonin as a Bio-Regulatory Molecule in Skin and Hair Aesthetics International Journal of Science and Research (IJSR) · 2026
    17. Melatonin and the Human Hair Follicle Journal of Drugs in Dermatology · 2023
    18. Hydrophilic melanin as a potential hair growth stimulant: A secondary observational study Journal of Cosmetic Dermatology · 2024
    19. Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine Advanced Pharmaceutical Bulletin · 2016 · 15 citations
    20. Melanin Pigmentary Disorders: Treatment Update Dermatologic Clinics · 2005 · 84 citations
    21. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation 2004 · 60 citations
    22. Topical liposome delivery of molecules to hair follicles in mice Journal of Dermatological Science · 1997 · 60 citations
    23. [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs Biochemical Pharmacology · 2007 · 26 citations
    24. Bimatoprost Topical Journal of the Dermatology Nurses' Association · 2017
    25. Therapeutic effects of topical Mycophenolate mofetil on hydroquinone-induced depigmentation in Guinea pigs and mice Annals of Medicine · 2025
    26. 519 Design of a new molecule proven to be safe and effective for topical depigmenting and antiaging method Journal of Investigative Dermatology · 2022
    27. Oxidative stress in ageing of hair International Journal of Trichology · 2009 · 126 citations
    28. Hair loss at injection sites of mesotherapy for alopecia Journal of Cosmetic Dermatology · 2017 · 18 citations
    29. Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study Journal of Cosmetic Dermatology · 2025
    30. Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review International Journal of Women's Dermatology · 2018 · 66 citations