Clinical Studies Using Topical Melatonin

    Giovanni Greco, Ritamaria Di Lorenzo, Lidia Ricci, Teresa Di Serio, Eleonora Vardaro, Sonia Laneri
    TLDR Melatonin cream may help prevent skin damage but its anti-aging and hair growth effects are unclear.
    Melatonin, commonly used orally as a sleep aid, has been studied for its topical applications in treating skin disorders due to its antioxidant and anti-inflammatory properties. Clinical studies have shown its efficacy in preventing or reducing skin damage such as dermatitis, erythema, and sunburn when applied to the skin before exposure to radiation (UV, sunlight, and high-energy beams). However, the evidence for its use as a skin anti-aging or hair growth-promoting agent is less clear, due to limitations in study design or the use of melatonin in combination with other active ingredients. One trial suggests a potential beneficial role of melatonin in treating some forms of alopecia in women. Further research is needed to definitively determine the benefits of topical melatonin for skin aging and hair loss.
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