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Glossary Topical Antifungals

medications applied to skin to treat fungal infections

Topical antifungals are medications applied directly to the skin to treat fungal infections. These treatments, which can come in the form of creams, ointments, or lotions, work by killing or inhibiting the growth of fungi that cause conditions like athlete's foot, ringworm, and yeast infections.

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Research

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research Formulation And Evaluation Of Emulgel Of An Antifungal Drug For Topical Drug Delivery

3 citations , January 2023 in “Journal of Pharmaceutical Negative Results”

This study reports that fluconazole emulgel formulations, using jojoba oil and liquid paraffin, showed effective drug release and improved characteristics for treating skin diseases compared to traditional oral formulations.

research Immediate and residual antifungal activity of compounds used for whole body and adjuvant topical therapy against Microsporum canis: an in vitro study

5 citations , January 2020 in “Veterinary Dermatology”

In this study, researchers evaluated the antifungal effectiveness of topical products on infected kitten hair, finding most were effective after one application, with enilconazole and lime sulfur showing residual activity; however, 0.15% ketoconazole with chlorhexidine had no such lasting effect.

research Minimal systemic exposure of a new topical triazole antifungal, efinaconazole 10% solution, in patients with severe onychomycosis following 28-day treatment

February 2013 in “Journal of The American Academy of Dermatology”

Hair loss is a common but often unreported side effect of cancer treatments, especially for breast and prostate cancers.

research Comparative therapeutic evaluation of an ethnoveterinary herbal spray and conventional topical antifungal therapy for bovine dermatophytosis

July 2026 in “International Journal of Advanced Biochemistry Research”

This study found that a herbal spray for treating bovine dermatophytosis was safe and economical, though conventional antifungal therapy had a higher cure rate.

research Severe Adult Kerion Celsi With Rapid Improvement During Systemic Antifungal and Adjunctive Secretome Therapy: A Case Report

July 2026 in “Cureus”

In this case report, a 48-year-old woman with kerion celsi showed improvement with a regimen including antifungal, bacterial, and adjunctive treatments, though the specific role of mesenchymal stromal cell secretome could not be isolated from the other therapies.

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Community Join

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community Malassezia safe topical treatments?

2 upvotes 7 years ago

The user is seeking Malassezia-safe treatments for hair loss and currently uses a baby shampoo, a scalp tonic with antifungal ingredients, and aloe gel. They consider using Kirkland Minoxidil 5% drops and possibly consulting a doctor about Finasteride.

community Derm says my hair loss (diffuse) is from seborrheic dermatitis. Anyone else have experience with this? I was already prepared to jump on fin min

in Research/Science 26 upvotes 1 year ago

Seborrheic dermatitis can cause hair loss, and treatments like ketoconazole shampoo, topical steroids, and oral antifungals may help. Some consider using finasteride and minoxidil for hair loss despite dermatitis.

community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 8 months ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community 4 months of 1mg of fin a day and 5 months of topical minoxidil

in Progress Pictures 1053 upvotes 9 months ago

Significant hair regrowth was achieved using 1mg of finasteride daily, 3ml of topical minoxidil, ketoconazole shampoo, vitamin D, and castor oil, with no side effects. Results appeared after two months, leading to discussions on treatment effectiveness and commitment.

community Can Shampoo Treat Suspected Fungal Hair Loss?

in General 64 upvotes 1 year ago

Hair loss possibly caused by a fungal infection might be treated with antifungal shampoos or oral medications. If not fungal, treatments like minoxidil or finasteride may be necessary.

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Learn

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin mainly hydrates the hair and scalp; no study has shown that it increases hair thickness or changes follicle function.

learn Valproic acid

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.

learn Vitamin B12

Can topical products containing Vitamin B12 improve scalp health and hair growth? Topical Vitamin B12 may not significantly improve hair growth unless there's a deficiency.

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