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This narrative review reports that tissue-engineered scaffolds for wound healing generally match standard care outcomes, with some trials indicating faster healing and improved scar quality, despite challenges like limited cellular infiltration and inadequate vascularization.

This study constructed a 3D-printed scaffold using sodium alginate, gelatin, and alginate lyase hydrogel, which supports hair follicle regeneration in artificial skin, suggesting a promising strategy for tissue-engineered skin with functional appendages.

This review highlights the potential of bioengineered dermal scaffolds in tissue engineering to enhance wound healing by mimicking the dermal structure and supporting cellular processes, while also discussing recent advancements and challenges in scaffold technology.

This study demonstrated that using a perfusion culture bioreactor and 3D spheroid culture can enhance corneal endothelial cell expansion and support the construction of tissue-engineered corneal endothelial layers in vitro.

Corrections were made to a previous work on 3D printing a gel-alginate mix for creating hair follicles, but the main finding - that this method can help grow hair - remains the same.

This review discusses strategies for regenerating cutaneous nerve function in burn patients and highlights the potential role of autologous skin-derived adult stem cells in improving sensory recovery, but reports no new experimental findings.

This review highlights the need for improved methods in cosmetic safety assessment, emphasizing the potential of engineered skin tissue for more effective detection and toxicological evaluation of cosmetic products, compared to traditional methods.

This report introduces a tissue-engineered nerve conduit combining hfNCSCs-derived neurons and acellular nerve grafts to potentially repair long-distance peripheral nerve injuries.

This study demonstrated that transplanting in vitro differentiated Wharton's jelly mesenchymal stem cells on acellular dermal grafts led to complete skin regeneration with appendages in a mouse model of full-thickness wounds.

This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.

This study found that using 3D Gel-C6S-HA scaffolds seeded with VEGF165-modified rat hair follicle stem cells enhanced angiogenesis and vascularization in tissue-engineered skin, improving wound healing.

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.

This study demonstrated that a 3D bioprinting technique using a gelatin/alginate hydrogel scaffold can regenerate entire hair follicles in mice, offering potential advancements in hair loss treatment.

This chapter describes methods for creating engineered skin substitutes with chimeric hair follicles using human and murine cell grafts in immunodeficient mice, but reports no clinical outcomes.

This review discusses advances in skin tissue engineering, focusing on scaffold-free approaches and the application of stem cells, and reports no new research findings.

This review discusses recent advancements in using macromolecules for hair loss treatment, highlighting microneedle and nanoparticle delivery systems, tissue-engineered scaffolds for hair follicle regeneration, and artificial skin platforms as drug screening methods.

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

This review discusses current concepts in wound repair and suggests that these evolving paradigms might also explain regenerative processes in various organ systems, but it reports no new research findings.

This review explores the potential of multifunctional bioscaffolds in skin tissue engineering, highlighting their successful biological performance in vitro and in vivo animal models, while also identifying the demand for technological advancements to improve wound healing applications in clinical settings.

This study found that a new-type artificial xenogenic derma exhibited better biocompatibility and dermal tissue regeneration ability compared to cross-linked acellular dermal matrix in a mouse model.

This review discusses nanoparticle-based wound-healing materials, detailing their benefits, limitations, and recent advancements, and emphasizes the need for further understanding to enhance therapeutic outcomes.

This study found that using engineered skin with PGA-collagen scaffolds, combined with hair follicle stem cells and other cell types, effectively repaired full-thickness skin defects in nude mice.

This study observed that tissue-engineered skin, using VEGF165 gene-modified cells embedded in astragalus polysaccharide-containing 3D printed scaffolds, enhanced early vascularization, and collagen and hair follicle regeneration, leading to improved skin repair in nude mice with full skin defects.

This chapter reviews traditional and tissue-engineered treatments for skin defects and discusses advances in bioengineered skin constructs, but it presents no new experimental results.

This study developed HA-gel-dex hydrogels with enhanced ECM-like properties and functionality, showing promise for 3D bioprinting, tissue repair, and as wound dressings due to improved cell interaction, cytocompatibility, antimicrobial synergy, and wound healing in mice compared to traditional ECM bio-inks.

This review discusses the advancements in biologic skin substitutes for wound treatment and their potential in enhancing cutaneous regeneration but reports no new clinical results.

In this study, researchers successfully constructed a high-precision three-dimensional model of human skin dermis, revealing a detailed analysis of dermal porosity and pore diameter distribution, which can aid the development of biomimetic tissue-engineered skin.

This study found that hair follicle stem cells can proliferate and differentiate into keratinocytes on chitosan skin-engineered templates, suggesting potential applications in regenerative medicine.

In this study, FN-based fiber scaffolds designed using Rotary Jet-Spinning were shown to enhance wound healing and reduce scar formation in a mouse model, suggesting potential for regenerating healthy skin structure.

This review examines the role of endothelial precursors and cellularized scaffolds in wound repair and revascularization for treating full thickness skin loss, but reports no new clinical results.