Preparation and Experimental Study on a New Type of Artificial Derma

    January 2006 in “ Chinese Journal of Aesthetic Medicine ”
    HU Yang-hong
    TLDR The new artificial derma is better for skin regeneration and biocompatibility.
    The study aimed to develop a new type of artificial xenogenic derma using an acellular dermal matrix (ADM) immersed in type I collagen solution. The experiment compared this new ADM with one cross-linked with glutaraldehyde by embedding them in the subcutaneous tissue of Mus musculus albus. Results showed that all mice experienced early-stage hair loss, which lasted longer with cross-linked ADMs. After 4 weeks, the new-type ADMs demonstrated longer degradation times and more natural-like collagen regeneration compared to cross-linked ADMs. The conclusion was that the new-type ADM exhibited better biocompatibility and a stronger ability to regenerate dermal tissue, making it suitable for use as a scaffold in tissue-engineered skin.
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