Decellularized Wharton's Jelly Matrix as a Three Dimensional Scaffold for Wound Healing and Hair Regeneration Applications

The study explored the use of Wharton's jelly mesenchymal stem cells (WJMSCs) seeded onto a decellularized Wharton's jelly matrix (DWJM) for skin regeneration and hair growth. WJMSCs, known for their self-renewal and proliferation potential, were ectodermally differentiated in osteogenic media. In a mouse model, WJMSCs cultured on DWJM or an acellular dermal graft (DG) generated cells indicative of ectodermal differentiation. While DWJM alone did not result in skin regeneration, the combination of differentiated WJMSCs on DG led to complete skin regeneration with hair follicles and sebaceous glands. The study highlighted the potential of using WJMSCs with DWJM and DG for full-thickness wound healing, although the development of skin appendages was more pronounced with DG.