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This study developed microneedles loaded with Platycladus orientalis leaf extract to treat androgenic alopecia, finding that they can effectively deliver active ingredients into the dermis, promote hair follicle growth by removing free radicals, and activate the Wnt/β-catenin pathway.

In this study involving acne patients, researchers compared the effects of combined fire needle and salicylic acid therapy with conventional treatment, measuring improvements in skin lesion severity, skin barrier function, and microbiota diversity; results are not reported in the abstract.

This study found that microneedle delivery of Polygonum multiflorum extract led to earlier pigmentation and hair regrowth in mice with androgenetic alopecia.

This paper reports on the structural characteristics of α-type filaments in the inner root sheath cells of guinea pig hair follicles without presenting new clinical findings.

This review reports that microneedle-mediated transdermal drug delivery systems show promise in enhancing alopecia treatments by improving the efficacy of various therapeutic agents, including drugs, biologics, and stem cells, but highlights a gap between basic research advancements and clinical trial focus.

This article reviews recent developments in microneedles combining metallic elements and herbal compounds for wound healing, highlighting their benefits such as enhanced therapeutic efficacy and reduced toxicity, and offering a reference for future advancements in this technology.

This study engineered a programmable platform using miniaturized needle arrays for drug delivery, showing improved wound healing outcomes in diabetic mice compared to standard topical treatments.

This study developed a gas-propelled microneedle patch with puerarin/quercetin nanoparticles, which demonstrated improved hair-regenerating effects in an androgenetic alopecia mouse model by increasing drug delivery, alleviating oxidative stress, promoting angiogenesis, and rejuvenating senescent cells.

In this study, researchers developed a probiotic-based microneedle system combining Weissella cibaria and clascoterone to target androgenetic alopecia, which in a mouse model improved hair density, vascular regeneration, and reduced inflammation, suggesting a promising treatment approach.

In this study, researchers developed a leech-inspired microneedle platform for targeted delivery of metformin to hair follicle cells, which showed promising results in reducing inflammation and oxidative stress and promoting hair growth, offering a potential new treatment strategy for androgenetic alopecia.

In this study, transcutaneously applied nanoparticles and viral vectors were shown to penetrate murine hair follicles, internalize in antigen-presenting cells, and induce immune responses, suggesting a promising approach for vaccine delivery.

This study found that microneedling treatment improved hair regeneration in an animal model of alopecia areata and positively influenced the gut microbiome by restoring microbial diversity and altering short-chain fatty acid levels.

This study found that nanoemulsions of different sizes vary in their ability to penetrate skin layers, with smaller sizes aiding transdermal delivery and potential applications in transcutaneous immunization.

This study demonstrated that a new topical treatment using ketotifen-loaded microneedles, designed for prolonged release, significantly reduced inflammatory markers in an animal model of allergic conjunctivitis, suggesting enhanced therapeutic delivery and sustained ocular benefits.

This study reported that injecting monofilament threads into the scalp significantly improved hair count and hair mass index in women with female pattern hair loss, with most participants noticing substantial improvements in hair characteristics compared to a placebo.

In this study, alternating PRP with microneedling produced faster hair growth results in patients with mild to moderate androgenetic alopecia compared to PRP alone.

This article discusses the premade slit method in hair restoration surgery, emphasizing the importance of a tailored depth control instrument for optimal follicle implantation, but provides no new clinical results.

This study described a novel three-dimensional-printed microneedle system designed for improved transdermal delivery of minoxidil to treat hair loss, demonstrating effective hair regrowth and safety in a mouse model while allowing sustainable needle base recovery.

This study found that intradermal polynucleotide injections were linked to improvements in the appearance around the eyes and increased patient satisfaction, with minimal adverse effects, suggesting potential for further research to validate efficacy and optimize treatment protocols.

This review discusses advancements in the use of microneedle arrays and nanoparticles for transdermal delivery of therapeutics, noting challenges in overcoming the skin barrier and summarizing recent clinical trial achievements in areas like cancer therapy and gene therapy.

This systematic review explored the feasibility of adding skin needling to an aesthetic clinic's offerings, examining financial implications, time investment, and its integration with existing treatments. Various challenges and learning opportunities were noted, underscoring the complexity of introducing a new service.

In this study, microneedling was found to be an effective alternative for treating alopecia areata, with most patients experiencing increased hair growth and density within affected areas within three months.

This study found that scanning electron microscopy can identify four specific hair morphology patterns in alopecia areata patients, offering a less invasive diagnostic option compared to punch biopsy.

A new microneedle system effectively delivers finasteride to treat hair loss.

In this summary of needle mesotherapy's role in treating alopecia, the researchers highlight its use in delivering beneficial substances directly to the skin or hair follicles, showing hair loss reduction after one treatment and hair regrowth after several sessions, although contraindications exist for certain populations.

This study proposes a metal-organic gel-encapsulated microneedle system with antibacterial, anti-inflammatory, and pro-angiogenic properties for treating infected wounds, demonstrating potential for precise and adaptive management by targeting various stages of wound healing.

This paper contains author contact information and disclosures without reporting new research findings or results.