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This study found that concentrated clusters of noradrenergic nerve fibers form a longitudinal linear system in rat skin, particularly innervating arrector pili muscles.

This study reported that using non-absorbable magnesium microneedle patches for 12 weeks improved under-eye wrinkles as measured by a grading scale and wrinkle index, with minimal discomfort and no significant change in dermal thickness.

This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.

This review found that microneedling can stimulate various biological pathways to promote tissue remodeling, enhance skin regeneration, and benefit conditions like wound healing and skin rejuvenation, with emerging uses in targeted drug delivery and periodontal therapy.

In this open uncontrolled study on microneedling as an adjuvant therapy for frontal fibrosing alopecia, researchers observed stable frontotemporal recession measurements while patients reported improvements in quality of life and a reduction in inflammatory activity parameters.

This case study found that pharmacopuncture and needle-embedding therapy improved hair loss and physical condition in a woman with androgenetic alopecia, but further clinical studies are needed.

In this study involving 20 participants with alopecia areata, microneedling was reported to clinically improve hair density and growth in affected areas, with results starting around one month and concluding three months after the final treatment session.

This report highlights a preterm newborn with hair-thread tourniquet syndrome affecting multiple toes, emphasizing the importance of early identification and removal to prevent severe complications.

In this case report, researchers documented a rare instance of trans-epidermal elimination of insulin formulation in a 45-year-old woman with diabetes, suggesting that insulin or its excipients may have caused a granulomatous reaction leading to skin lesions at injection sites and impaired diabetes control.