39 citations
,
March 2022 in “Nature Protocols” This study describes a protocol for generating hair-bearing skin organoids from human pluripotent stem cells, achieving full complexity resembling fetal skin tissue by day 130 in vitro.
10 citations
,
August 2020 in “Journal of Bioscience and Bioengineering” This study reports that using activated platelet-rich plasma releasate in the preparation of bioengineered hair follicle germs enhanced follicular gene expression and significantly improved hair regeneration in vitro.
2 citations
,
September 2025 in “International Journal of Nanomedicine” This review discusses the roles of extracellular vesicles in skin health and disease and reports no clinical results; the authors highlight potential therapeutic uses and call for more research.
52 citations
,
November 2006 in “International Journal of Cosmetic Science” This review discusses the identification and classification of different wrinkle types based on histological features and microanatomy, emphasizing their varying responses to treatments, and reports no new clinical results.
42 citations
,
July 2021 in “Frontiers in Cell and Developmental Biology” This review examines the regeneration capabilities of skin, oesophagus, and oral mucosa, highlighting the oral mucosa's unique scarless healing properties and the potential of cell therapy to improve scar reduction in wound healing.
21 citations
,
August 2020 in “Stem Cell Research & Therapy” This meta-analysis suggests that stem cell therapy may reduce burn wound area and improve healing-related factors in preclinical models, indicating potential for future clinical studies on burn treatment.
18 citations
,
October 2021 in “Frontiers in Physiology” This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.
91 citations
,
December 2010 in “Stem Cells” This study found that Wnt signaling regulates the symmetric division of adult neural stem cells, increasing their numbers during subependymal regeneration, stroke response, and colony formation.
47 citations
,
September 2011 in “Acta biomaterialia” This study observed that increasing the γ-kerateine content in meta-kerateine materials led to reduced elasticity, solidity, and hydrolytic stability, and decreased hepatocyte attachment support.
4 citations
,
October 2022 in “American journal of physiology. Heart and circulatory physiology” This study found that in patients with severe aortic valve stenosis, higher serum dihydrotestosterone levels were associated with increased myocardial hypertrophy, fibrosis, and reduced left ventricular function.
22 citations
,
March 2023 in “Bioengineering” This review discusses stem cell therapy as a promising treatment for epidermolysis bullosa, highlighting preliminary successes in treating skin lesions but noting the need for further research on effectiveness and safety.
18 citations
,
July 2022 in “Chemistry - an Asian journal” This study found that GelMA/HAMA bioink shows promise for 3D printing skin equivalents, as it effectively mimics the native skin's properties and supports hair follicle structure development.
13 citations
,
April 2025 in “International Journal of Nanomedicine” In this study, a hydrogel with anti-inflammatory, antibacterial, antioxidant, and wound tissue adhesion properties was developed, showing significant potential for wound healing and suggesting it could offer a new and effective treatment option in clinical settings.
February 2024 in “Medicina” In this study, researchers used atomic force microscopy to capture and analyze morphological changes in the surface of healthy hair, identifying features such as pitting and rod-shaped macro-fibrillar elements, which could inform future research on hair conditions and care.
9 citations
,
November 2024 in “Journal of Wound Management Official journal of the European Wound Management Association” Cold Plasma shows promise for healing wounds by killing bacteria and helping tissue grow.
6 citations
,
January 2021 in “Journal of the mechanics and physics of solids/Journal of the Mechanics and Physics of Solids” This study's simulations suggest that biomechanical factors, like follicle geometry and tissue stiffness, are likely significant in hair fiber protrusion, providing a framework for future experimental validation.
November 2025 in “Advanced Healthcare Materials” This review explores advancements in bioprinting technologies for developing in vitro skin models that replicate immune-mediated skin diseases, highlighting their potential to reduce animal testing and enhance research and product testing capabilities in dermatology.
December 2025 in “Russian Journal of Skin and Venereal Diseases” This study found that in patients with non-cicatricial alopecia, hair follicles and their sheaths were thinner compared to controls, especially in cases of alopecia areata and telogen effluvium, with notable thinning beginning in the subcutaneous fat tissue.
517 citations
,
February 2010 in “Materials” This review discusses the history and development of keratin biomaterials for biomedical uses, highlighting their biological activity and biocompatibility, and provides no new research findings.
76 citations
,
February 2024 in “International Journal of Molecular Sciences” This review discusses the growing importance of hydrogel scaffolds in skin wound healing, highlighting their unique properties and recent advancements in their use for treating difficult tissue damage, particularly within tissue engineering.
62 citations
,
August 2023 in “International Journal of Nanomedicine” This review discusses the potential of Pluronic F127-derived hydrogels for wound healing, examining their applications in various wound types and exploring underlying mechanisms and their interaction within the wound microenvironment.
36 citations
,
April 2013 in “Cell and Tissue Research” Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.
3 citations
,
November 2025 in “Biomimetics” This review discusses the potential of hydrogel-based interventions for radiation-induced skin injury, providing no new clinical results but highlighting their synergistic mechanisms and promise in improving treatment strategies.
2 citations
,
May 2025 in “IntechOpen eBooks” This article highlights that early and high-dose corticosteroid therapy, along with immunosuppressive agents, is crucial for managing Vogt-Koyanagi-Harada disease, and emerging biological therapies may benefit refractory cases.
2 citations
,
June 2023 in “Gels” This study highlights the versatility and potential of injectable hydrogel nanocomposites in biomedical research, emphasizing their roles in controlled drug delivery, tissue regeneration, and treatment of various conditions, such as cardiac issues, joint diseases, and bone regeneration.
1 citations
,
April 2023 in “Preprints.org” This study found that the guided SEFFI technique for facial volume restoration and anti-aging is minimally invasive with a low complication rate, suggesting it as a promising treatment option.
1 citations
,
February 2023 in “International Journal of Molecular Sciences” This review summarizes the research on bioactive materials that modulate the skin microenvironment to promote wound healing and highlights the essential role of the fascial layer, without presenting new experimental results.
August 2026 in “Journal of Functional Biomaterials” In this study, researchers developed a collagen and bacterial cellulose-based dressing loaded with bacitracin, which exhibited enhanced antibacterial activity, improved wound healing, and reduced inflammation in a murine infected-wound model, suggesting its potential for clinical use in treating infected wounds.
April 2025 in “Journal of Biophotonics” This study found that 808 nm laser photobiomodulation altered mitochondrial respiration and enhanced osteogenic protein expression in human dental pulp stem cells, with the effects being dose-specific and more pronounced at 15 J/cm².
February 2024 in “Plastic and Reconstructive Surgery – Global Open” This systematic review found that both cellular and acellular stem cell-based therapies are safe and able to improve hair regeneration and density in patients with androgenic alopecia, although some results may be temporary.