Stem Cell Therapies for Epidermolysis Bullosa Treatment
March 2023
in “
Bioengineering
”
stem cell therapies Epidermolysis Bullosa genetic skin disorder blister formation gene therapies cell therapies hematopoietic stem cells mesenchymal stem cells regenerate damaged tissues immune response modulation clinical trials genetically corrected keratinocytes fibroblasts mutant genes Junctional EB
TLDR Stem cell therapies may help improve symptoms and quality of life for people with epidermolysis bullosa.
Stem cell therapies show promise for treating Epidermolysis Bullosa (EB), a genetic skin disorder characterized by blister formation. Current treatments are symptomatic, but advances in gene and cell therapies, including hematopoietic and mesenchymal stem cells, offer new possibilities. These therapies aim to regenerate damaged tissues and modulate the immune response. Clinical trials are evaluating the efficacy of genetically corrected keratinocytes and fibroblasts, with some success in correcting mutant genes in Junctional EB. However, challenges such as safety concerns, optimizing protocols, and ensuring long-term efficacy remain, necessitating further research.
