Serum Dihydrotestosterone Levels Are Associated With Adverse Myocardial Remodeling in Patients With Severe Aortic Valve Stenosis Before and After Aortic Valve Replacement
October 2022
in “
American journal of physiology. Heart and circulatory physiology
”
dihydrotestosterone DHT myocardial hypertrophy myocardial remodeling aortic valve stenosis SAVR left ventricular muscle mass fibrosis left ventricular function moesin vimentin heart muscle thickening heart muscle remodeling aortic valve narrowing surgical aortic valve replacement heart muscle mass heart tissue scarring heart function
TLDR Higher DHT levels are linked to worse heart changes in severe aortic valve stenosis patients.
The study investigated the role of serum dihydrotestosterone (DHT) levels in myocardial hypertrophy and remodeling in 43 patients with severe aortic valve stenosis (AS) undergoing surgical aortic valve replacement (SAVR). Results showed that higher DHT levels were positively correlated with increased left ventricular muscle mass, fibrosis, and reduced left ventricular function. Proteomic analysis revealed associations between higher DHT levels and increased levels of hypertrophy-associated protein moesin and fibrosis-associated protein vimentin. Post-SAVR, higher preoperative DHT levels were linked to reduced left ventricular function and increased fibrosis. The findings suggest that DHT may be a target for preventing adverse myocardial remodeling in AS patients.
