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GlossaryCardiac Hypertrophy

thickening of heart muscle due to increased workload

Cardiac Hypertrophy, also known as Myocardial Hypertrophy, is the thickening of the heart muscle, specifically the myocardium. This condition can result from increased workload on the heart due to high blood pressure or other cardiovascular diseases, leading to an enlarged heart that may struggle to pump blood efficiently. While it can be a compensatory response to increased demand, prolonged hypertrophy can lead to heart failure and other complications.

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Serum Dihydrotestosterone Levels Are Associated With Adverse Myocardial Remodeling in Patients With Severe Aortic Valve Stenosis Before and After Aortic Valve Replacement

research Serum Dihydrotestosterone Levels Are Associated With Adverse Myocardial Remodeling in Patients With Severe Aortic Valve Stenosis Before and After Aortic Valve Replacement

4 citations, October 2022 in “American journal of physiology. Heart and circulatory physiology”

Higher DHT levels are linked to worse heart changes in severe aortic valve stenosis patients.

research Targeting Cardiac Hypertrophy Through a Nuclear Co-Repressor

3 citations, October 2019 in “EMBO molecular medicine”

Targeting NCoR1 can help treat heart enlargement and dysfunction.

research Gender Differences in Cardiac Hypertrophy

27 citations, February 2020 in “Journal of Cardiovascular Translational Research”

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice

research Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice

13 citations, August 2018 in “Journal of Molecular and Cellular Cardiology”

Finasteride improves heart function and repairs damage after heart attack in mice.

research Sex Hormones and Related Compounds, Including Hormonal Contraceptives

January 2015 in “Side effects of drugs annual”

The document concludes that sex hormones and related compounds have various effects on health, with both potential benefits and risks.

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