Hydrogel-Based Strategies for the Prevention and Treatment of Radiation-Induced Skin Injury: Progress and Mechanistic Insights

The document reviews the potential of hydrogel-based strategies for preventing and treating radiation-induced skin injury (RISI), a common complication of radiotherapy affecting 85-95% of patients. Hydrogels are highlighted for their biocompatibility, high water content, and ability to facilitate tissue repair through antioxidation, anti-inflammation, angiogenesis, and tissue remodeling. Various hydrogel formulations, including protein-based, synthetic, and smart hydrogels, are explored for their therapeutic benefits and ability to deliver drugs effectively. Despite their promise, challenges such as stability, safety, and regulatory approval remain. The review emphasizes the need for interdisciplinary collaboration to translate these innovations into clinical practice, shifting from symptomatic management to mechanism-based strategies.