July 2024 in “International Journal of Molecular Sciences” This study explored the effects of DPP, a 15-PGDH inhibitor, on human follicle dermal papilla cells damaged by dihydrotestosterone and observed that DPP enhanced wound healing, reduced reactive oxygen species, and increased hair growth in ex vivo human hair follicle cultures.
April 2024 in “Clinical, cosmetic and investigational dermatology” This study found that salvianolic acid B significantly enhanced hair growth and delayed hair follicle cycle progression in mice and human hair models, suggesting potential as a treatment for hair loss.
This study found that Solanum nigrum L. extracts showed potential as 5 alpha-reductase inhibitors, similar to finasteride, and highlighted their promise for treating androgenic diseases like benign prostatic hyperplasia and male pattern hair loss.
November 2023 in “Scientific Reports” In this study, researchers used NIH hairless mice to uncover genetic markers associated with hair loss and identified a Lama3 point mutation as a potential genetic contributor, creating a mutant mouse model that may advance the study of androgenetic alopecia.
September 2023 in “Stem Cells International” This study using human and animal models found that adipose-derived stem cell exosomes promoted hair growth and counteracted dihydrotestosterone's inhibitory effects, suggesting potential therapeutic applications for androgenetic alopecia.
July 2023 in “Pharmacognosy Magazine” This study found that Cerasus serrulata extracts, when obtained through specific methods, demonstrate significant antioxidative and antibacterial properties, as well as potential anti-alopecia effects in a mouse model, potentially making them useful supplements for these purposes.
This study found that while finasteride effectively improves hair growth in male androgenetic alopecia, it may affect fertility at higher doses, and the evidence on its long-term sexual side effects is inconsistent and requires more rigorous research.
January 2022 in “Biomedical Reports” This study suggests that inaudible sound at 30 kHz may promote hair growth and inhibit hair loss signals in human dermal papilla cells, indicating potential as a new treatment for androgenic alopecia.
February 2015 in “American journal of medical and biological research” This study found that molecular differences in paracrine factors between balding and non-balding hair follicles may enhance understanding of androgen action in hair disorders and potentially inform better treatments.
63 citations
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December 2010 in “Journal of Endocrinology” This study found that decreased allopregnanolone levels through inhibition or intrauterine growth restriction in guinea pigs were linked to altered brain development markers, suggesting a role for neurosteroids in fetal brain protection and development.
58 citations
,
February 2021 in “Toxins” This review concluded that botulinum toxins have various potential off-label uses for dermatological conditions, but further research is needed to fully establish their efficacy and safety in these applications.
36 citations
,
March 2014 in “Molecular and Cellular Biology” This study found that Cidea is critical for regulating lipid storage and sebum secretion in sebaceous glands, with its deficiency causing hair issues and impaired skin functions in mice.
32 citations
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June 2024 in “Pharmaceutics” This review explores the use of topical and transdermal delivery for drugs and cosmetics, highlighting the benefits of avoiding side effects and rapid metabolism, with a focus on nanoparticulate formulations and techniques for studying skin penetration.
30 citations
,
June 2010 in “Endocrine Related Cancer” In this study, dutasteride more effectively reduced prostate cancer cell viability than finasteride in vitro, but did not significantly alter the angiogenic response.
24 citations
,
March 2021 in “Frontiers in Cell and Developmental Biology” This study found that Wnt signaling, crucial for lung development, may be disrupted in severe asthma, potentially affecting cell proliferation and senescence through complex mechanisms.
24 citations
,
November 2019 in “Experimental Dermatology” This review synthesizes current research on PPAR-γ signaling in hair follicle biology and its potential role in treating hair growth disorders like scarring alopecia and hirsutism, but reports no new clinical results.
22 citations
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May 2019 in “Animals” In this study, researchers found that high hair cortisol levels, indicating stress in cows, were associated with certain shelter and cow-level conditions such as unclean environments and physical injuries.
10 citations
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June 2016 in “PLOS ONE” In this in-vitro study, researchers identified finasteride as the most effective FDA-approved drug for expanding functional myeloid-derived suppressor cells, suggesting its potential future use in immunosuppressive therapies.
9 citations
,
July 2024 in “JAAD reviews.” This review discusses the role of extracellular vesicles in dermatology for therapeutic, diagnostic, and prognostic purposes, highlighting the lack of validated findings and the necessity for more rigorous clinical trials.
9 citations
,
June 2022 in “Plants” This study found that shallot extract may promote hair growth in androgenetic alopecia by reducing inflammation and modulating gene expression related to key hair growth pathways.
7 citations
,
September 2022 in “Communications biology” This research found that Leydig cells significantly rely on synthesizing omega-6 HUFAs to support male steroid hormone production, highlighting a new role for these fatty acids in the male reproductive system.
7 citations
,
January 2022 in “Plants” This study found that extracts from the rice variety Bue Bang 3 CMU, particularly the husk and bran, demonstrated antioxidant, anti-inflammatory, and anti-androgenic properties, suggesting potential use in treating androgenetic alopecia.
6 citations
,
August 2024 in “Experimental Dermatology” This study found that irisin, a myokine, increases hair growth by activating the Wnt/β-catenin pathway, enhancing cell proliferation and hair shaft elongation in both human cell and mouse models.
5 citations
,
January 2025 in “Science Advances” In this study, researchers observed that acute stress increased levels of the enzyme 5αR2 in the medial prefrontal cortex of male rats, affecting stress reactivity, but this effect was not seen in females.
3 citations
,
May 2023 in “International Journal of Molecular Sciences” In this study, researchers observed that phospholipid-calcium carbonate hybrid nanoparticles effectively delivered Tofacitinib citrate topically, which significantly inhibited hair follicle apoptosis and promoted hair growth in a mouse model of chemotherapy-induced alopecia, compared to a traditional Tofacitinib solution.
3 citations
,
January 2012 in “Journal of Investigative Dermatology” Inhibiting PGD2 and using dermal papilla cells may improve skin and hair regeneration.
2 citations
,
March 2022 in “Laboratory Animal Research” This study suggests that a mild intramuscular dose of botulinum toxin improved spermatogenesis and sperm parameters in ageing mice.
2 citations
,
April 2022 in “Genes” This study identifies a polygenic basis for atypical recurrent flank alopecia in Cesky Fousek dogs through genome-wide association analysis and gene expression profiling, highlighting several metabolic pathways involved in the condition.
1 citations
,
August 2025 in “The Egyptian Journal of Internal Medicine” This paper reviews obesity diagnosis and screening methods, emphasizing BMI's practicality in low- and middle-income countries, but provides no new clinical results.
1 citations
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August 2024 in “Pharmaceuticals” This study found that goat placenta extract, when combined with PEGylated liposomes and microspicule gel, significantly promoted hair regrowth in patients experiencing hair loss due to chemotherapy by enhancing hair cell proliferation without causing skin irritation over a 12-week application period.